UPUS ANTICOAGULANTS (LA) and anticardioL lipin (ACL) antibodies (ACLA) belong to a heterogenous group of antibodies directed against negatively charged pho~pholipids.l-~ However, more recent studies would suggest that these antibodies are directed to epitopes of other proteins that are complexed with negatively charged phospholipid~>-~ Although antiphospholipid antibodies are frequently found i...

Antiphospholipid syndrome (APS) is recognized as one of the main determinants of hypercoagulable conditions. The literature reports the incidence of this syndrome in a third of patients who underwent surgery for peripheral revascularization. Antiphospholipid antibodies are divided into two categories in relation to specific diagnostic tests. The first group is called lupus anticoagulant and con...

• Throughout the developing world women die during pregnancy and in childbirth from hemorrhage (20-35%), unsafe abortion (10-15%), eclampsia or hypertension (10-15%), infection (10-15%), and obstructed labor (10-15%) (see Technical Note 1). Those that survive spend their reproductive years suffering from chronic anemia and the debilitating consequences of complications associated with reproduct...

Objective. To study the predictive factors for avascular necrosis (AVN) of bone in patients with systemic lupus erythematosus (SLE). Method. The records of 38 SLE patients who developed clinically apparent AVN during the course of their disease were reviewed. Information on clinical presentation, corticosteroid usage and autoantibody profiles was obtained, and comparison was made between these ...

Fluctuations of lupus anticoagulant activity and anticardiolipin antibody titres were studied in 53 patients with systemic lupus erythematosus (SLE). The median study time was 26 months with a median number of 12 samples. Lupus anticoagulant was measured by the kaolin clotting time (KCT) and dilute Russell viper venom time (dRVVT) assays; anticardiolipin antibodies were assayed by an enzyme lin...

The classical clinical picture of the antiphospholipid syndrome (APS) is characterized by venous or arterial thromboses, fetal losses and thrombocytopenia, in the presence of antiphospholipid antibodies (aPL), namely lupus anticoagulant, anticardiolipin antibodies or antibodies directed to various proteins, mainly β2 glycoprotein I, or all three. Apart from being "primary" (without any discerna...