In the phase 3 LYM-3002 study comparing intravenous VR-CAP with R-CHOP in patients with newly-diagnosed, measurable stage II-IV mantle cell lymphoma, not considered or ineligible for transplant, the median progression-free survival was significantly improved with VR-CAP (24.7 versus 14.4 months with R-CHOP; P<0.001). This post-hoc analysis evaluated the association between the improved outcomes...

Mastitis is one of the most prevalent diseases in dairy cattle and cause considerable economic losses. Alongside somatic cell count (SCC), differential (DSCC) has been recently introduced as a new indicator intramammary infection. The DSCC expressed or proportion (%) polymorphonuclear neutrophils plus lymphocytes (PMN-LYM) milk cells. These numbers are complemented to total 100 by macrophages (...

Low uptake of monoclonal antibodies (MAbs) in cancer lesions is a significant problem in cancer therapy. Recent studies have shown that antibody uptake in tumor is controlled in large part by the tumor blood flow and the vascular permeability of the tumor endothelium. We have hypothesized that these physiological properties of tumor vessels may be altered by pretreatment with vasoactive drugs o...

We were intrigued by the recent report of Hjalgrim et al. (1) that showed familial clustering of multiple sclerosis and young-adult-onset Hodgkin lym-phoma in Denmark and that supported Newell ' s 1970 hypothesis (2) of a shared etiology. Their study and another report by Vineis et al. (3) indicate a familial association between multiple sclerosis and non-Hodgkin lymphoma. Given the etiologic i...

Idelalisib—a fi rst-in-class selective inhibitor of phosphoinositide-3kinase delta, which is expressed only in haemopoietic cells—has been shown to be eff ective for treatment of B-cell malignancies in two clinical trials. First, in a single-group phase 2 study, researchers enrolled 125 patients with refractory, indolent non-Hodgkin lymphoma. Idelalisib (150 mg orally, twice daily) induced an o...

Human chorionic gonadotropin (hCG) may boost progesterone production and attenuate maternal-immune response against concepti in ewes, increasing prenatal survival. The present study examined effects of repeated hCG administration after mating on serum progesterone concentration and complete blood counts (CBC) during early gestation, as well as offspring numbers at parturition. Fifty-six ewes we...

an RNA related in sequence to that of the Rauscher leu kemia virus. The viral-related RNA found in these lym phomas is a 70 S component encapsulated with RNA-instructed DNA polymerase in a particle possessing a den sity characteristic of the RNA tumor viruses. Further more, the DNA synthesized by the lymphoma particles hy bridizes specifically to the RNA of the Rauscher leukemia virus. The part...

3-Hydroxypy rid ine-2-carboxaldehyf le thiosemicarbazone (3-HP) has been shown to be active against leukemia L1210, Ehrlich ascites carcinoma, lym]>homa L5178Y, the Lewis lung carcinoma, and adenocarcinoma 755. 3-HP is active, in some in stances, by gavage and also by delayed treatment. 3-HP is a member of a broad class of a-(.Y)-heterocyclic carboxaldehyde thiosemicarbazones, several of which ...

cases. (b) The Wassermann reaction negative, m 318 cases, but of these 149 gave a history of venereal diseases, and 31 cases showed evidence of hereditary syphilis, with such lesions as Hutchinson's peg-top-shaped teeth, flat noses, ozsena, linear scars at the angles the mouth, nodes on the long bones, swelling of the joints, enlarged lym~ phatic glands, and deafness. 169 cases gave a history o...