Wolbachia endosymbionts carried by filarial nematodes give rise to the neglected diseases African river blindness and lymphatic filariasis afflicting millions worldwide. Here we identify new Wolbachia-disrupting compounds by conducting high-throughput cell-based chemical screens using a Wolbachia-infected, fluorescently labeled Drosophila cell line. This screen yielded several Wolbachia-disrupt...

OBJECTIVE To determine the relationship between human lymphatic filariasis, caused by Wuchereria bancrofti, and falciparum malaria, which are co-endemic throughout West Africa. METHODS We used geographical information systems and spatial statistics to examine the prevalence of lymphatic filariasis in relation to malaria prevalence, mosquito species distributions, vegetation and climate. RES...

The main function of the lymphatic system is to control and maintain fluid homeostasis, lipid transport, and immune cell trafficking. In recent years, the pathological roles of lymphangiogenesis, the generation of new lymphatic vessels from preexisting ones, in inflammatory diseases and cancer progression are beginning to be elucidated. Sphingosine-1-phosphate (S1P), a bioactive lipid, mediates...

Lymphatic vasculature is increasingly recognized as an important factor both in the regulation of normal tissue homeostasis and immune response and in many diseases, such as inflammation, cancer, obesity, and hypertension. In the last few years, in addition to the central role of vascular endothelial growth factor (VEGF)-C/VEGF receptor-3 signaling in lymphangiogenesis, significant new insights...

From the Sabin Vaccine Institute, and George Washington University, Washington, DC (P.J.H.); Liverpool School of Tropical Medicine Lymphatic Filariasis Support Centre and the Global Alliance to Eliminate Lymphatic Filariasis, Liverpool, United Kingdom (D.H.M.); the Schistosomiasis Control Initiative, Imperial College London, London (A.F.); the International Trachoma Initiative, New York ( J.K.)...

From the Sabin Vaccine Institute, and George Washington University, Washington, DC (P.J.H.); Liverpool School of Tropical Medicine Lymphatic Filariasis Support Centre and the Global Alliance to Eliminate Lymphatic Filariasis, Liverpool, United Kingdom (D.H.M.); the Schistosomiasis Control Initiative, Imperial College London, London (A.F.); the International Trachoma Initiative, New York ( J.K.)...

VEGFs (vascular endothelial growth factors) are master regulators of vascular development and of blood and lymphatic vessel function during health and disease in adults. This family of five mammalian ligands acts through three RTKs (receptor tyrosine kinases). In addition, co-receptors such as NRPs (neuropilins) associate with the ligand-receptor signalling complex and modulate the output. Ther...

background: in addition to determining the exact tumor location and its geometric features, an increase of the effective tumor atomic number will enhances the chance in treating the tumoral cells under suitable radiation. in the present study, we assessed metrezoate-labeled gallium transmission in burkett lymphatic cells. materials and methods: human burkitt lymphatic cells were grown in cultur...

lymphatic filariasis (lf), a nematode disease transmitted by arthropod vectors, is repeatedly reported in immigrant population. this disease is not endemic in iran; however, different species of mosquitoes, capable of transmission of parasite mi-crofilaria, are distributed in the country. hereby, incidental detection of an im-ported case of lf due to wuchereria bancrofti in an indian worker in ...