The uptake and tissue distribution of [3H]methotrexate [( 3H]MTX) at doses of 5 mg/kg i.p. either free or linked to anti-EL4 immunoglobulin G (AELG) or normal rabbit globulin (NRG) was studied in EL4 lymphoma-bearing C57BL/6J mice. When the uptakes of MTX-AELG, MTX-NRG, and free MTX were assayed as cell-associated 3H activity, comparison 3 hr after administration showed that uptake of MTX admin...

A 52-year-old woman underwent bilateral lung transplantation for rheumatoid arthritis–associated interstitial lung disease. Her pretransplant course was notable for immunosuppressive therapy for rheumatoid arthritis with adalimumab, azathioprine, and prednisone. She exhibited extensive pretransplant allosensitization, including 3 low-intensity donorspecific antihuman leukocyte antigen antibodie...

INTRODUCTION Acute rejection (AR) is a major determinant of renal allograft survival. The incorporation of new immunosuppressive agents explains the improvement seen in the results of transplantation in recent years. OBJECTIVE To assess the optimal immunosuppression regimen according to the immunological risk of renal transplant patients. METHOD We performed a retrospective study of 977 con...

OBJECTIVE To evaluate the outcome of children with severe acquired aplastic anemia treated with rabbit antithymocyte globulin and cyclosporine as first-line treatment at this institution. METHODS Retrospective analysis of 26 pediatric patients with aplastic anemia, treated between 1996 and 2011 with rabbit antithymocyte globulin plus cyclosporine. RESULTS The overall response rate at six mo...

This review informs about the chemical composition of plasma proteins majorly albumin and globulin. Blood proteins, also called are found in blood plasma. While, serum present human body very high quantities for other proteins. Hundreds dissolved but only two major protein groups i.e. Albumin Globulin. is a important component (55% proteins) it made by liver. There an immediate correlation betw...

We describe a point mutation creating an additional ATG codon in the 5' untranslated region (UTR) of the HAMP gene, in a patient with juvenile hemochromatosis. By transient in vitro transfection studies, we provide evidence that the additional ATG is functional and prevents normal hepcidin production by inducing an aberrant translation initiation of the pre-hepcidin mRNA.

It was possible to gauge the inhibition of mouse beta-glucuronidase expression by injecting RNA, made from both strands of subclones of a cosmid containing the complete gene, into mouse blastomeres at the four-cell stage. Although our initial screen did not identify the 5' region, we were able to isolate a subclone containing homology to 20 bp coding for N-terminal amino acids of rat and human ...

Autophagy is a highly regulated process about which relatively little is known, particularly concerning the transcriptional control of autophagy regulation. A new study identifies a key regulator of the expression of autophagy-related genes, thereby providing insights into the signalling pathways modulating autophagy.

Forty-six patients with venous immunosickness” variety. The heterophile antibody logically mediated or lymphoproliferative was composed of a mixture of gamma G diseases received goat antihuman thymoand gamma M antibodies and was partially cyte antisera globulin (ATG) therapy. absorbed by ATG. Serum sickness did not Heterophile antibody production occurred occur in any of these patients, in spit...

Recently published paper by Haller and coworkers in Journal of Clinical Investigation reported that a combination of low-dose anti-thymocyte globulin (ATG) and pegylated granulocyte-colony stimulating factor (G-CSF) may preserve β-cell function in patients with established type 1 diabetes.