Concentrations of ethanol similar to those in the blood of intoxicated patients suppressed phytohemagglutinin- or streptolysin O-induced lymphocyte transformation, and inhibited bone marrow granulocyte colony growth in soft agar. Inhibition of lymphocyte transformation and granulocyte colony growth occurred despite the presence of large concentrations of folate and other vitamins. These in vitr...

Methods We investigated 3 groups of patients for identifying the food hypersensitivity. 1. Group 60 patients with symptoms of irritable bowel syndrome (IBS) without a diagnosis of organic gastrointestinal disease. 2. Group 19 patients with atopic dermatitis, polysenzitization to inhalant, not to food allergens. 3. Group 6 infants (3-12 months old) with intestinal symptoms (bloody stool and abdo...

The beryllium lymphocyte transformation test was performed on 16 patients with chronic beryllium disease, 10 subjects (seven patients and three young boys) who were under suspicion, and 117 healthy beryllium workers. The tests gave a positive response in all patients with definite disease and a negative response in the suspected group. Two of the healthy workers had a positive response, indicat...

Lymphocyte transformation studies of nonadherent lymphocytes from chronic Chagasic and uninfected persons demonstrated that responses of all individuals to a mouse heart homogenate showed a correlation with responses to streptococcal antigens. Considering the known cross-reactions between streptococcal and cardiac antigens and the high reactivity of Chagasic patients to streptococcal antigens, ...

Phytohaemagglutinin-induced lymphocyte transformation was studied in 19 patients with systemic lupus erythematosus (SLE) in relation to disease activity, peripheral blood lymphocyte count, serum iron and folate levels, and corticosteroid treatment. Similar studies were performed on a group of 28 age- and sex-matched controls and on 10 patients with facial palsy who were examined before and afte...

PPD-sensitized monocytes and macrophages from tuberculin-positive subjects are both capable of inducing blastogenic transformation of autologous lymphocytes . Incorporation of thymidine-3H and morphological transformation were always greater in lymphocyte cultures containing macrophages than in those containing monocytes . More lymphocytes entered the first detectable S phase in cultures contai...

ADRs: adverse drug reactions LTT: lymphocyte transformation test MDH: multiple drug hypersensitivity MDHS: multiple drug hypersensitivity syndrome MP: Mycoplasma pneumoniae PA: particle agglutination SJS/TEN: Stevens-Johnson syndrome/toxic epidermal necrolysis Tregs: regulatory T cells INTRODUCTION Many adverse drug reactions (ADRs), including Stevens-Johnson syndrome (SJS)/toxic epidermal necr...

PPD-sensitized monocytes and macrophages from tuberculin-positive subjects are both capable of inducing blastogenic transformation of autologous lymphocytes. Incorporation of thymidine-(3)H and morphological transformation were always greater in lymphocyte cultures containing macrophages than in those containing monocytes. More lymphocytes entered the first detectable S phase in cultures contai...