Observation: The CD30 antigen is a type-1 transmembrane glycoprotein which is a member of the tumor necrosis factor receptor family and may be expressed on activated B and T cells. CD30+ lymphoproliferative disorders (CD30+ LPDs) mainly include primary cutaneous CD30+ anaplastic large-cell lymphoma (pcALCL) and lymphomatoid papulosis (LyP). Other CD30 +LPD showing skin lesions are large cell tr...

RNA interference has been used to dissect the importance of individual gene products in various human disease processes, including cancer. Small-interfering RNA, or siRNA, is one of the tools utilized in this regard, but specially-designed delivery agents are required to allow the siRNA to gain optimal access to the cell interior. Our laboratory has utilized two different siRNA-binding delivery...

The performance of a variety of high-level composite procedures, as well as lower-cost density functional theory (DFT)- and second-order perturbation theory (MP2)-based methods, for the prediction of absolute and relative R-X bond dissociation energies (BDEs) was examined for R = Me, Et, i-Pr and t-Bu, and X = H, CH(3), OCH(3), OH and F. The methods considered include the high-level G3(MP2)-RAD...

Environmental changes associated with modern lifestyles may underlie the rising incidence of Type 1 diabetes (T1D). Our previous studies of T1D families and the BioBreeding (BB) rat model have identified a peripheral inflammatory state that is associated with diabetes susceptibility, consistent with pattern recognition receptor ligation, but is independent of disease progression. Here, compared...