Background Vascular endothelial growth factor (VEGF) is considered to play an essential role in the pathogenesis of agerelated macular degeneration due to its vascular permeability-inducing and angiogenic properties. Ranibizumab, a small antibody fragment designed to competitively bind all VEGF isoforms, passes after intravitreal injection into all retinal layers reaching the retinal pigment ep...

Forty-three additional members of a family described originally by Sorsby and Mason have been examined in order to typify pseudoinflammatory macular dystrophy more accurately. Six new affected members were identified by history alone and a further 7 were examined. Vision is lost from disciform macular degeneration generally during the 5th decade of life. Thereafter peripheral degeneration occur...

PURPOSE To determine the safety and efficacy of the application of transcutaneous (transpalpebral) microcurrent stimulation to slow progression of dry and wet macular degeneration or improve vision in dry and wet macular degeneration. METHODS Seventeen patients aged between 67 and 95 years with an average age of 83 years were selected to participate in the study over a period of 3 months in t...

Macular degeneration is one of the most common retinal diseases in India. Usually it is observed in people over 60s and is therefore called age related macular degeneration, ARMD or AMD. The macula is responsible for the sharp central vision needed for detailed activities such as reading, writing, driving, face recognition and ability to see colours. Age related macula degeneration is degenerat...

PURPOSE To study macular function of X-linked congenital retinoschisis (CRS) by focal macular electroretinogram (MERG). METHODS MERGs were recorded with 5 degrees, 10 degrees, and 15 degrees spots in 20 patients with CRS. Seventeen patients showed foveal schisis with little or no change in foveal fluorescein angiography (Group 1), and three patients showed advanced macular changes with nonspe...

BACKGROUND Age-related macular degeneration is the most prevalent form of visual impairment and blindness in developed countries. Genetic studies have made advancements in establishing the molecular cause of this disease, identifying mutations in the complement factor H (CFH) gene and a locus on chromosome 10 encompassing the HTRA1/LOC387715/ARMS2 genes. Variants in complement 3 (C3) and an HLA...

Citation: Qiu F, Matlock G, Chen Q, et al. Therapeutic effects of PPARa agonist on ocular neovascularization in models recapitulating neovascular agerelated macular degeneration. Invest Ophthalmol Vis Sci. 2017;58:5065– 5075. DOI:10.1167/iovs.17-22091 PURPOSE. This study was designed to evaluate effects of fenofibric acid (Feno-FA), a peroxisome proliferator–activated receptor-alpha (PPARa) ago...

The purpose of this article is to review the pathways underlying age-related macular degeneration and potential therapeutic targets, focusing on the complement pathway and the recent MAHALO Phase II trial of the investigational drug lampalizumab. This trial was the first to have shown positive results for the treatment of geographic atrophy in age-related macular degeneration. It has potential ...

This review highlight the similarities in the pathogenesis between Alzheimer disease and age-related macular degeneration. All studies published between 1990 and 2014 were reviewed to identify the common pathological pathways. Alzheimer disease and age-related macular degeneration share common features such as vitronectin and amyloid-β accumulation, increased oxidative stress, and apolipoprotei...

Recently, the Treatment of Age-Related Macular Degeneration with Photodynamic Therapy (TAP) Study Group reported that photodynamic therapy with verteporfin (Visudyne; Ciba Vision, Bülach, Switzerland) can reduce the risk of vision loss in patients with subfoveal choroidal neovascularization (CNV) due to age-related macular degeneration (AMD). This is a review of the circumstances leading to the...