Alzheimer's disease (AD) is characterized by profound synapse loss and impairments of learning and memory. Magnesium affects many biochemical mechanisms that are vital for neuronal properties and synaptic plasticity. Recent studies have demonstrated that the serum and brain magnesium levels are decreased in AD patients; however, the exact role of magnesium in AD pathogenesis remains unclear. He...

Zoogloea ramigera, a gram-negative bacterium found in activated sludge, formed volutin granules when excess orthophosphate was added to a phosphate-starved culture. These volutin granules were stainable by hydrogen sulfide after lead acetate treatment and extractable by N-perchloric acid but were not adsorbed by activated charcoal. They appeared to consist of inorganic polyphosphate. Optimum gr...

Background and Aims Cesarean sections are performed mostly under spinal anesthesia. Shivering is one of the distressing complications. The aim of the study was to compare the efficacy of intravenous (i.v) magnesium sulfate and tramadol with placebo (normal saline) on postspinal shivering in elective cesarean section when used as prophylaxis. Methods One hundred and thirty-five pregnant women ...

HYPOTHESIS Intravenous magnesium sulfate improves objective measures of expiratory flow in patients with acute severe exacerbations of asthma. DESIGN Randomized, double-blind, placebo-controlled trial. SETTING Urban emergency department. PARTICIPANTS Forty-eight asthmatic patients aged 18 to 60 years with initial peak expiratory flow rate (PEFR) < 200 L/min who failed to double their init...

Maternal mortality in Brazil is a major problem. It is about 10 times that of Canada or England. What do these three countries have in common regarding maternal mortality? Hypertension in pregnancy, a major cause of maternal death in developed and developing countries. Among the hypertensive complications of pregnancy, pre-eclampsia and eclampsia are of utmost importance when considering any st...

BACKGROUND Intracellular magnesium ([Mg]i) plays an important role in the regulation of myocardial metabolism, contractility, and the maintenance of transsarcolemmal and intracellular ionic gradients. An understanding of the role of magnesium in the clinical setting, however, is hampered by the lack of an assay of intracellular tissue magnesium levels. METHODS AND RESULTS We used energy-dispe...

BACKGROUND Current evidence suggests that intravenous magnesium sulfate might be effective for reducing migraine pain. In a recent pilot study, we showed that intravenous caffeine citrate could reduce the severity of migraine headache. The objective of this study is to investigate the efficacy of intravenous caffeine citrate vs. magnesium sulfate for management of acute migraine headache. MET...

BACKGROUND Research suggests that fetal exposure to magnesium sulfate before preterm birth might reduce the risk of cerebral palsy. METHODS In this multicenter, placebo-controlled, double-blind trial, we randomly assigned women at imminent risk for delivery between 24 and 31 weeks of gestation to receive magnesium sulfate, administered intravenously as a 6-g bolus followed by a constant infus...

BACKGROUND Preterm labor is the leading cause of infant morbidity and mortality so it may be necessary to administer tocolytics for treatment of it. OBJECTIVE The aim of this study was to compare the efficacy and safety of magnesium sulfate and nifedipine in the management of preterm labor. MATERIALS AND METHODS 100 women with documented preterm labor were randomly assigned to receive magne...