Objective To examine the validity of 5-component SARC-F questionnaire for screening sarcopenia among patients with chronic kidney disease (CKD). Methods Eligible participants were enrolled from Department Nephrology, Ruijin Hospital, Shanghai Jiao Tong University School Medicine March 2019 to November 2019. Evaluations performed using self-administered questionnaire. Sarcopenia was diagnosed by...

Introduction. Due to chronic inflammation, maintenance hemodialysis (MHD) patients continue show excess mortality. Acetate-free citrate-buffered A concentrates could be a way improve the biocompatibility of procedure, reduce and thus in long term prognosis patients. Methods. Using pre-post design (3 months acetate followed by 3 citrate-acidified standard bicarbonate-based dialysate hemodialysis...

the general population has changed since the 1950s [1]. Hyperuricemia was originally considered to be a consequence of renal insufficiency and associated with a variety of cardiovascular diseases, and several studies suggested that hyperuricemia can cause hypertension, renal insufficiency and metabolic syndrome. However, the role of serum uric acid remains unclear in the maintenance hemodialysi...

BACKGROUND Methicillin-resistant Staphylococcus aureus is a leading cause of death in patients undergoing hemodialysis. However, controversy exists about the optimal dose of vancomycin that will yield the recommended pre-hemodialysis serum concentration of 15-20 mg/L. OBJECTIVE To develop a data-driven model to optimize the accuracy of maintenance dosing of vancomycin for patients undergoing ...

BACKGROUND Bioimpedance analysis (BIA) has been reported as helpful in identifying hypervolemia. Observation data showed that hypervolemic maintenance hemodialysis (MHD) patients identified using BIA methods have higher mortality risk. However, it is not known if BIA-guided fluid management can improve MHD patients' survival. The objectives of the BOCOMO study are to evaluate the outcome of BIA...

AIMS To analyze the relationship between oral active vitamin D treatment and mortality in maintenance hemodialysis (MHD) patients. METHODS We examined the association of oral calcitriol treatment with mortality in 156 MHD patients (80 men and 76 women; mean age: 59 ± 15 years). The survival analysis of all-cause and cardiovascular mortality was performed using the Kaplan-Meier survival and Co...

The recently published data of Donadio in Critical Care provide convincing evidence that neutrophil gelatinaseassociated lipocalin (NGAL), an established key biomarker of acute kidney injury (AKI) in the critically ill, can be effectively removed by renal replacement therapy (RRT) [1]. His findings challenge recent work by Schilder et al. [2] and corroborate our concern regarding the potential ...

The independent association between the indices of iron stores or administered intravenous iron, both of which vary over time, and survival in patients who are on maintenance hemodialysis (MHD) is not clear. It was hypothesized that the observed associations between moderately high levels of three iron markers (serum ferritin, iron, and iron saturation ratio) or administered intravenous iron an...

BACKGROUND Recently, acetate-free citrate containing dialysate (A(-)D) was developed. We have already reported about the significant effect of A(-)D on metabolic acidosis, anemia, and malnutrition in maintenance hemodialysis (MHD) patients. In this study, we compared the effect of A(-)D and acetate containing dialysate (A(+)D) on serum calcium and intact-parathyroid hormone (int-PTH) levels. ...

BACKGROUND Systemic inflammation and muscle wasting are highly prevalent and coexist in patients on maintenance hemodialysis (MHD). We aimed to determine the effects of systemic inflammation on skeletal muscle protein metabolism in MHD patients. METHODS Whole body and skeletal muscle protein turnover were assessed by stable isotope kinetic studies. We incorporated expressions of E1, E214K, E3...