Two hundred and seventy four asymptomatic Ghanaian school-children aged 5 to 17 years were screened for malaria parasites by examination of blood films. One hundred and fifty five microscopically-positive individuals were treated with dihydroartemisinin-piperaquine and followed for 3 weeks. Retrospective species-specific PCR of all 274 screened samples identified an additional 60 children with ...

Abstract Background As malaria incidence and transmission in a region decreases, it becomes increasingly difficult to identify areas of active transmission. Improved methods for identifying monitoring foci are needed low parasite prevalence order achieve elimination. Serological assays can provide population-level infection history inform elimination campaigns. Methods A bead-based multiplex an...

Whole blood samples (N = 295) were obtained from different locations in Amazonas and Sucre States, in Venezuela. Malaria was diagnosed by microscopy, OptiMAL and polymerase chain reaction (PCR), with Plasmodium vivax, P. falciparum, and P. malariae being detected when possible. We identified 93 infections, 66 of which were caused by P. vivax, 26 by P. falciparum, and 1 was a mixed infection. No...

Studies on autochthonous malaria in low-transmission areas in Brazil have acquired epidemiological relevance because they suggest continued transmission in what remains of the Atlantic Forest. In the southeastern portion of the state of São Paulo, outbreaks in the municipality of Juquitiba have been the focus of studies on the prevalence of Plasmodium, including asymptomatic cases. Data on the ...

The malarial parasite continues to be one of the leading causes of death in many developing countries. With the development of resistance to the currently available treatments, the discovery of new therapeutics is imperative. Currently, the plasmepsin enzymes found in the food vacuole of the parasite are a chief target for drug development. Allophenylnorstatine-based compounds originally design...

Blood samples from 182 patients presenting at the out-patient clinic in Richard-Toll, Senegal were analysed by Thick smear microscopy, the QBC, PCR and the new dipstick PATH Malaria® assay which detects the histidine rich protein II antigen of Plasmodium falciparum. Thick smear microscopy was used as the reference method. Sensitivity, specificity, predictive positive and negative values were 10...

grew and developed their immunity. Without an understanding of malarial immunity and its relatively slow development the clinician is lost in such a locality. Falciparum malaria swamped the P ovale and P malariae infections also found in west Africa. Nearly every child had clinical falciparum malaria during the first 18 months of life, which resolved with 12X5 mg of pyrimethamine in those days....

Malaria remains one of the major killers of humankind and persists to threaten the lives of more than one-third of the world's population. Given that human malaria can now be caused by five species of Plasmodium, i.e., Plasmodium falciparum, Plasmodium vivax, Plasmodium malariae, Plasmodium ovale, and the recently included Plasmodium knowlesi, there is a critical need not only to augment global...

Malaria in humans is mainly caused by infection with five Plasmodium species (Plasmodium falciparum, P. vivax, P. ovale, P. malariae and P.knowlsi). In 2015, an estimated 214 million new malaria cases and 584 000 deaths were recorded globally due to malaria. The ability to accurately detect malaria infection in all individuals and in all populations is fundamental to achieve elimination and era...

BACKGROUND The prevalence of malaria parasitaemia among blood donors in Ilorin has not been documented. In this study, we determined the prevalence of malaria parasitaemia among blood donors in Ilorin, as well as, the sociodemographic and other factors associated with it. METHOD This was a hospital-based cross sectional study involving 308 consenting blood donors. The sociodemographic charact...