Human Andrology 2011, 1:2–16 Objective To highlight the concept of unexplained male infertility and discuss the potential causes and its proper management. Design Review of literature. Results Male infertility of unknown origin is a condition in which fertility impairment occurs spontaneously or due to an obscure or unknown cause. It includes two categories, unexplained male infertility and idi...

The concept of autoimmune-related infertility has remained controversial. Traditionally, abnormal autoimmune function has been implicated as a contributing factor to female as well as male infertility. In the female, abnormal autoimmunity primarily relates to autoantibody activity against ovarian tissue components, whereas in the male, abnormal autoimmunity, believed to be clinically relevant, ...

Background: Infertility is increasingly recognized as a major health problem. Meiotic genes are very important candidates for genes contributing to female and male infertility. Mammalian MutL homologues have dual roles in DNA mismatch repair (MMR) after replication errors and meiotic reciprocal recombination. There are four MutL homologues in eukaryotes that mutations of three of them (Mlh1, Ml...

Gender biases impact doctors’ advising on infertility, thereby shaping treatment recommendations and patient health outcomes. This study explored the roles attributed to gender in personal opinions of male female medical residents Saudi Arabia. used content Appraisal analyses explore attitudes realised by 85 81 interns about infertility. Content contained six themes, including psychol...

Infertility is defined as the inability to conceive after 1 year of unprotected intercourse, a definition that is based on a monthly fecundity rate of 15 to 25%. Approximately 10 to 20% of couples may experience problems conceiving, and infertility can result from a wide variety of etiologies. Female factors account for 40% of infertility.1 When investigating infertility, evaluation of both the...