Male breast cancer (MBC) is considered as a rare disease that accounts for less than 1% of all breast cancers, and its treatment has been based on the evidence available from female breast cancer. Axillary sentinel lymph node biopsy (SLNB) is now regarded as the standard of care for both female and male patients without clinical and imaging evidence of axillary lymph node metastases, while inte...

The EMBO Molecular Medicine Conference on Common Molecular Mechanisms of Mammary Gland Development and Breast Cancer Progression was held jointly with a meeting of the COST B20 (European cooperation in the field of scientific and technical research)—a group of about 35 scientists from 23 European countries who have been meeting regularly during the past five years to discuss questions about mam...

Black cohosh is an herbal extract that is often used as an alternative to estrogen-based replacement therapies to treat hot flushes that frequently accompany the transition to menopause. Although cancer-free women as well as breast cancer patients and survivors use black cohosh to relieve vasomotor symptoms, there is limited information on its potential to influence breast cancer development or...

Breast cancer is a predominant cause of death in women across the globe. Chemoprevention by using natural, dietary or synthetic products has been appearing to be a fascinating approach to combat the growing burden of breast cancer. In the current study, we intended to explore the mechanisms of chemopreventive action of honokiol against 7, 12 - dimethylbenz[a]anthracene (DMBA)-induced mammary ca...

Hormonal, genetic, and environmental factors play major roles in the complex etiology of breast cancer. When treated continuously with 17beta-estradiol (E2), the ACI rat exhibits a genetically conferred propensity to develop mammary cancer. The susceptibility of the ACI rat to E2-induced mammary cancer appears to segregate as an incompletely dominant trait in crosses to the resistant Copenhagen...

Low-penetrance alleles associated with breast cancer risk have been identified in population-based studies. Most risk loci contain either no or multiple potential candidate genes. Rat mammary carcinoma susceptibility 1b (Mcs1b) is a quantitative trait locus on RN02 that confers decreased susceptibility when Copenhagen (COP)resistant alleles are introgressed into a Wistar Furth (WF)-susceptible ...

wnloade ention of breast cancer can be achieved with a better understanding of the factors contributing to l breast development. Because the breast develops postnatally, alterations in the development and e activity of the neuroendocrine system may set up an environment that increases cancer risk. The t study examined how two neonatal experiences over the first 3 weeks of life influence normal ...

Mouse mammary tumorigenesis as a result of mouse mammary tumor virus (MMTV) integrations has helped to identify a wide variety of interesting genes that play a role in mammary development and tumorigenesis. Several such genes int1/wnt1, wnt3, wnt 10B, int2/fgf3, fgf4, int3/notch and int6 have been shown to be genetically altered in naturally formed mammary tumors as a consequence of MMTV integr...

1 univ. of Ljubljana, Biotechnical Fac., Dept. of Animal Science., Groblje 3, SI-1230, Slovenia, e-mail: [email protected] 2 Same address as 1, e-mail: [email protected] Mammary tumors in ruminants The frequency of mammary neoplasia in different species varies tremendously. Among women, breast cancer features as one of the most frequent types of cancer globally. Breast cancer is th...

Several groups, including ours, have reported that iodine exhibited antiproliferative and apoptotic effects in various cancer cells only if this element is supplemented as molecular iodine, or as iodide, to cells that are able to oxidize it with the enzyme thyroperoxidase. In this study, we analyzed the effect of various concentrations of iodine and/or iodide in the dimethylbenz[a]anthracene (D...