In manufacturing systems, aisles are paths which used for the movement of workers, transportation devices, and materials. The aisle structure contributes to layout efficiency by reducing material handling costs, mean flow time amount space needed, providing smooth transportation. Therefore, achieve a good layout, it is essential determine position facilities such as machines workstations, but a...

The manufacturing of advanced explosives containing large amounts of metal powders to improve performance, such as PAX-3, have proven difficult to transition into production. Current manufacturing processes have had low yield which results in a high cost per unit and questionable product uniformity. Over the past year the Twin Screw Extruder (TSE) Team has been investigating the use of a TSE ma...

Molecular oxygen is involved in the propagation step of this reaction, and it is an integral part of the catalytic cycle that generates the oxidative degradation of drug substances in pharmaceutical formulations. Oxidative degradation of the active drug substance in a formulation decreases drug potency and reduces product shelf life (2). The rate of oxidative degradate formation is proportional...

Quality by Design (QbD) refers to a holistic approach towards drug development. QbD has become the answer to assist both industry and FDA to move towards a more scientific, risk based, holistic and proactive approach to pharmaceutical development. The concept promotes industry’s understanding of the product and manufacturing process starting with product development, basically building quality ...

This paper, we consider dynamic dispatching control of a fully flexible online manufacturing system. Hence, vendors, who supply the materials, play an important role in this system. So, selection of vendors is much important. In a periodically reviewed, online manufacturing system where materials are dispatched from a central control station to different manufacturing sales. After production pr...

In this paper, a generalized mathematical model formulation for cellular manufacturing system (CMS) using hierarchical production planning (HPP) approach is proposed. The model is applied to two different real case studies and is solved by using operation research optimization software (Lingo (12.0) program). The model is divided into three main steps as follows: data collection, mathematical m...

Biologic drugs, as with all other medical technologies, are subject to a number of regulatory, marketing, reimbursement (financing) and other demand-restricting hurdles applied by healthcare payers. One example is the routine use of cost-effectiveness analyses or health technology assessments to determine which medical technologies offer value-for-money. The manner in which these assessments ar...