Medial collateral ligament (MCL)injury, is one of the most common ligament injuries of the knee,mostly results from a valgus force.Restoration of function and going back to the pre-injury level of function is the aim of treatment in ligament injuries of the knee. There are multiple soft tissue structures in medial side that play an important role in connection with each other to retain medial s...

Ecotourism is a sub-component of the field of sustainable tourism. Ecotourism’s perceived potential as an effective tool for sustainable development is the main reason why developing countries are now embracing it and including it in their economic development and conservation strategies. Ecotourism, as an alternative tourism, involves visiting natural areas in order to learn, to study, or to c...

Quality of urban areas and improvement of it have always been considered as one of the main issues in the process of urbanization. It might be possible to consider this importance as the result of fundamental changes in intellectual patterns during the past two decades in one side and its proposal in all aspects of human life on the other side though this is one of the main influential concepts...

PURPOSE Mantle cell lymphoma (MCL) is considered to be incurable. ABT-737 is a BH3 mimetic that targets Bcl-2, which is overexpressed in MCL and implicated in drug resistance. The present work investigated the antitumor effect of ABT-737. EXPERIMENTAL DESIGN Six MCL cell lines and primary MCL cells (n = 13) were used. Sensitivity to ABT-737 was assessed, and expression levels of Bcl-2 and Mcl...

In this paper, we consider the transfer of environmental and cultural assets to the next generation as a potential measure of sustainability. We define “net assets” as the value of renewable and nonrenewable natural resources plus humanmade, intellectual, social, and cultural capital, minus any debts. We apply this approach by first reviewing survey data reflecting how cultural capital may yiel...

MCL-1 (myeloid cell leukemia-1), a member of the BCL-2 family, has three splicing variants, antiapoptotic MCL-1L, proapoptotic MCL-1S, and MCL-1ES. We previously reported cloning MCL-1ES and characterizing it as an apoptotic molecule. Here, we investigated the molecular mechanism by which MCL-1ES promotes cell death. MCL-1ES was distinct from other proapoptotic BCL-2 members that induce apoptos...