Throughout the modern history of biology, DNA has been given a front-row seat. Many biology textbooks and courses present the RNA molecule as an accessory to the DNA molecule. Although we take the roles of RNA for granted, its history is not as well known as that of DNA. Perhaps it was long overdue for a stellar RNA researcher such as James Darnell to undertake such a challenge. The book he has...

The microsomal enzyme uridine diphosphate (UDP) glucuronate glucuronyltransferase (E.C. 2.4.1.17) catalyzes formation of bilirubin mono-glucuronide from bilirubin and UDPglucuronic acid. Bilirubin glucuronoside glucuronosyltransferase (E.C. 2.4.1.95), an enzyme concentrated in plasma membrane-enriched fractions of rat liver, converts bilirubin monoglucuronide to bilirubin diglucuronide. Bilirub...

Rachel Gunn explores the indigenization of Hollywood genres, specifically the adaptation of the horror genre in a Canadian contest. Conflicts of nation intersect with those of gender as Gunn discusses the ways in which both John Fawcett’s Ginger Snaps (2000) and David Cronenberg’s film Dead Ringers (1988) invert the traditionally masculine horror genre by interrogating the concept of the monstr...

Gunn rats lack bilirubin UDP-glycosyltransferases, but diazo-negative derivatives of bilirubin have been described in their bile. In order to investigate this alternative disposal of bilirubin, crude bile samples from Gunn and Wistar rats were directly analysed by h.p.l.c. Besides bilirubin (in Gunn rats) or its glycosides (in Wistar rats), two major compounds were detected. A yellow one corres...

Compound words with irregular plural nouns in first position (e.g. mice-eater) are produced far more frequently than compound words with regular plural nouns in first position (e.g. *rats-eater), (Gordon, 1985). Using empirical evidence and neural net modelling, the studies presented here demonstrate how a single route, associative memory based account might provide an equally, if not more, val...

Flavonoids have poor bioavailabilities largely because of metabolism via UDP-glucuronosyltransferases (UGTs). This study aims to further understand the functions of UGT in metabolizing genistein and apigenin, two compounds metabolized more extensively in the gut than in the liver. Because Gunn rats are deficient in UGT1As, we determined whether this deficiency would result in less flavonoid glu...

Compound words with irregular plural nouns in first position (e.g. mice-eater) are produced far more frequently than compound words with regular plural nouns in first position (e.g. *rats-eater), (Gordon, 1985). Using empirical evidence and neural net modelling, the studies presented here demonstrate how a single route, associative memory based account might provide an equally, if not more, val...

The familiar white urinals, puce-colored walls, and the queasy odor of disinfectant in M207—the men’s room on the mezzanine floor of the University of Pittsburgh’s medical school. I remember standing in a ragged line of seven young men across from the toilet stalls, pants stripped to my ankles. This was the moment, the crux of the clinical trial, the procedure that had seemed so trivial a few w...