OBJECTIVE Angiogenesis or neovascularization has long been known to aid in progression and metastasis of malignant tumors. Tumor angiogenesis is a complex event mediated by angiogenic factors released from cancer cells and or by host immune cells. Mast cells may induce tumor progression and potentiate metastasis by stimulating angiogenesis. The purpose of the present study was to validate topog...

Corresponding Author: Mahi Balci Department of Pathology, Kirikkale Medical University, Yenisehir/Kirikkale, Turkey Ph: +90 507 8397706 Email: [email protected] Abstract: The histopathological assessment of Oral Lichen Planus (OLP) and oral lichenoid lesions is relatively subjective. The distinguishing criteria established by WHO effectively reproducible when all selection criteria were fulfi...

Correlative data suggest that cardiac mast cells are a component of the inflammatory response that is important to hypertension-induced adverse myocardial remodeling. However, a causal relationship has not been established. We hypothesized that adverse myocardial remodeling would be inhibited by preventing the release of mast cell products that may interact with fibroblasts and other inflammato...

Tissue Mast Cell ' was discovered by Ehrlich (1877) and it was proved by Jorpes, Holmgren and Wilander (1937) that the granules of the tissue mast cell has the properties of heparin. Since then, the theory has become decisive and of late many evidences suggesting that this cell contains much quantity of histamin of high density have been given and thus its chemical ' properties seem to have bec...

dssue from sham-operated (Sham), untreated-fistula (Fist), and bosentan (100 mg'kg-1'day-r)-treated animals Gist + Bos) was analyzed for mast cell density, MMP activity, and myocardial collagen volume ' : ' H;h;; ai''i and 5 days after the qeation of an aortocaval fistula. r When compared with untreated flstulas, bosentan treafrnent prevented the marked increase in LV mast cell density at I day...

Obesity is accompanied by adipocyte death and accumulation of macrophages and mast cells in expanding adipose tissues. Considering the differences in biological behavior of fat found in different anatomical locations, we explored the distribution of mast cells, solitary macrophages, and crown-like structures (CLS), the surrogates for dead adipocytes, in subcutaneous and abdominal visceral fat o...

Background and aim: The stroma of basal cell carcinoma (BCC) is rich in mast cells. Morpheaform BCC has been reported to contain much more mast cells than the other types of BCC, but their significance remains unknown. In this study we investigated the significance of mast cells related to BCC and possible relationship between increased number of mast cells and clinical and histological p...

Mast cells accumulate within solid tumors and can release many angiogenic factors, suggesting that they may modulate vascularization of tumors. Stem cell factor (SCF) stimulates mast cell migration, proliferation, and degranulation and therefore may influence mast cell behavior within tumors. We investigated the contribution of SCF to tumor angiogenesis by manipulating its level in mammary tumo...

Inflammatory or allergic conditions, as well as situations where healing and repair processes occur, are characterized by the presence of increased numbers of mast cells. Previous work on the effect of neuropeptides on mast cell mediator release showed that only substance P caused such release from intestinal mucosal mast cells [Shanahan, F., Denburg, J. A., Fox, J., Bienenstock, J. & Befus, A....

Mast cells are bone marrow derived hemopoietic (Kitamura, et al. [1-3]). The mast cell is one of the important in immune system. It from multipotent hematopoietic progenitor cells. produces a number cytokines to augment responses, growth, and differentiation other