The aim of the present study was to examine the associations between the maternal intake of fatty acids during pregnancy and the risk of preclinical and clinical type 1 diabetes in the offspring. The study included 4887 children with human leucocyte antigen (HLA)-conferred type 1 diabetes susceptibility born during the years 1997-2004 from the Finnish Type 1 Diabetes Prediction and Prevention S...

OBJECTIVE The aim if the study was to investigate whether children born to older mothers have an increased risk of type 1 diabetes by performing a pooled analysis of previous studies using individual patient data to adjust for recognized confounders. RESEARCH DESIGN AND METHODS Relevant studies published before June 2009 were identified from MEDLINE, Web of Science, and EMBASE. Authors of stu...

A substantial body of evidence suggests that an abnormal intrauterine milieu elicited by maternal metabolic disturbances as diverse as undernutrition, placental insufficiency, diabetes or obesity, may program susceptibility in the fetus to later develop chronic degenerative diseases, such as obesity, hypertension, cardiovascular diseases and diabetes. This paper examines the developmental progr...

OBJECTIVE To examine the possible effects of maternal characteristics and obstetric and medical history on maternal cardiovascular parameters at 35-37 weeks' gestation. METHODS In 3013 singleton pregnancies at 35-37 weeks, maternal characteristics and medical history were recorded; uterine artery pulsatility index, mean arterial pressure (MAP) and maternal cardiovascular parameters were measu...

caudal regression syndrome (caudal dysplasia sequence) is a rare congenital malformation. it has a spectrum ranging from simple anal atresia to the absence of sacral, lumbar and possibly lower thoracic vertebrae and the most severe form called sirenomelia (mermaid syndrome). sirenomelia has a sole characteristic, which is the limbs fusion, with multiple internal structural abnormalities particu...

a:4:{s:10:"Background";s:164:"This study aimed to investigate maternal outcomes of pregnancy after in vitro fertilization (IVF) in primigravida women admitted to 3 different hospitals in Tehran.";s:19:"MaterialsAndMethods";s:399:"This study is a retrospective cross sectional analytical study to evaluate and compare the maternal outcomes (preeclampsia, multiple pregnancy, diabetes, pregnancy, de...

A t the time of diagnosis, the typical patient seen by a pediatric gastroenterologist for nonalcoholic fatty liver disease (NAFLD) is 12 years old. One of the most common questions that parents ask is: ‘‘when did this begin?’’ Rarely is there a clear answer; however, there is increasing evidence that NAFLD could begin at birth or even in utero. In this issue of the Journal of Pediatric Gastroen...

Much to Learn! In the preinsulin era, pregnancy in a diabetic mother had a bleak outcome for both the mother and the baby. Availability of insulin and modern methods of treatment improved the survival of these babies, but they appear to be at increased risk of obesity and diabetes (1–3). Spread of the diabetes pandemic to the young means there is now a growing epidemic of gestational diabetes m...