In order to combat a variety of pests, pesticides are widely used in fruits. Several extraction procedures (liquid extraction, single drop microextraction, microwave-assisted extraction, pressurized liquid extraction, supercritical fluid extraction, solid-phase extraction, solid-phase microextraction, matrix solid-phase dispersion, and stir bar sorptive extraction) have been reported to determi...

The use of hot-melt extrusion for preparing homogeneous API-excipient mixtures is studied for miconazole-PEG-g-PVA [poly(ethylene glycol)-poly(vinyl alcohol) graft copolymer] solid dispersions with a 5 cm(3) table-top, twin-screw corotating microcompounder (DSM Xplore). Phase behavior of PEG-g-PVA, miscibility of miconazole in PEG-g-PVA and the partitioning of miconazole between PEG and PVA amo...

the purpose of the present study was to investigate the effect of polyethylene glycol (peg) molecular weights (6000, 12000 and 20000) as solid dispersion (sd) carriers on the dissolution behavior of simvastatin. sds with various drug : carrier ratios were prepared by solvent method and evaluated for dissolution rate. differential scanning calorimetry (dsc), x-ray diffraction (xrd), infrared spe...

This paper deals with rigidity percolation in composite materials consisting of a dispersion of mineral particles in a microstructured viscoelastic matrix. The viscoelastic matrix in this specific case is a hydrocarbon refinery residue. In a set of model random composites the mean interparticle surface-to-surface distance was controlled, changing particle volume fraction phi and particle number...

The aim of this investigation was to improve the dissolution properties of the water-insoluble drug ezetimibe (EZE) and potentially improve bioavailability. A combination of melt and adsorption techniques was employed for the preparation of solid dispersions. PEG 4000, PEG 6000, and Gelucire 44/14 were used as hydrophilic carriers, and lactose monohydrate was used as an adsorbent. Phase solubil...

acetonitrile used as a solvent in manufactures and affects to central nervous system from inhalation exposure. the aim of this study was to develop a micro-solid phase extraction method for  the determination of acetonitrile in the air matrix. the sampling was performed with a small diameter fused silica fiber coated with a thin film of stationary phase and was subsequently desorbed and analyze...