The choice of appropriate animal models for the initial in vivo testing of potential anticonvulsant compounds is one of the most important steps in the successful search for new antiepileptic drugs. The purpose of this paper is to describe the most important aspects to take into account when performing the maximal electroshock seizure (MES) test in the routine laboratory screening of new antiep...

MPEP, a selective non-competitive antagonist of group I metabotropic glutamate receptor subtype 5 (mGluR5), administered at doses ranging from 0.75 to 1 mg/kg, failed to influence the electroconvulsive threshold in mice. However, when administered at higher doses (1.25 and 1.5 mg/kg), it significantly increased the threshold. Moreover, MPEP (applied at its highest subprotective dose of 1 mg/kg)...

A modified cortical ramp stimulation (CRS) model has been developed allowing repeated determinations of seizure threshold at short time intervals in individual rats without inducing postictal threshold increases. Anticonvulsant potency of the standard antiepileptic drugs carbamazepine, phenytoin, phenobarbital, valproate, diazepam and ethosuximide in the CRS model was compared with respective d...

Background: Recently, there has been much more interest in the use of medicinal plants in search of novel therapies for human neurodegenerative diseases such as epilepsy. In the present study, we investigated the anticonvulsant effects of Viola tricolor (V. tricolor) on seizure models induced by pentylenetetrazol (PTZ) and maximal electroshock stimulation (MES). Methods: Totally, 260 mice were ...

Introduction: This study was designed to investigate the possible anticonvulsant effect of acute administration of an aqueous extract of flowers of Alcea aucheri (EFA) in a seizure model. Methods: Seizures were induced in male adult Swiss mice by administration of pentylenetetrazol (PTZ) or Maximal Electroshock (MES). Mice were randomly subjected to receive saline, EFA (8.75-175 mg.kg-1), or d...

Group-housed adult male Sprague-Dawley rats were given a series of 4 exposures to electroconvulsive shock therapy or equivalent handling without shock (sham treatment). Twenty-four hours after the final treatment the rats were given vehicle or one of two doses of morphine intraperitoneally, and motor activity was assessed by remote sensing for 60 min. A significant shift of the normal dose-resp...

objective: newbouldia laevis seem, is an ubiquitous perennial plant belonging to the family bignoniaceae with varying applicability in ethnomedicine. methods: the anticonvulsant effect of the aqueous extracts of root and stem bark preparations was undertaken using standard techniques. results: results showed that the ld50 in mice was 489.8mg/kg body weight while 5.6mg/kg body weight protected m...

This study evaluated the sedative, and anticonvulsant activities of aqueous (AESM) ethanol (EESM) dried leaf extracts Solenostemon monostachyus. The sedative effect was with ketamine-induced hypnosis (100 mg/kg, i.p.). Also, activity using pentylenetetrazole (PTZ)-induced convulsion (85 i.p.), strychnine-induced (2 i.p.) maximal electroshock (MES)-induced models. AESM (200 p.o.) gave 66.67% pro...