نتایج جستجو برای: mbl2
تعداد نتایج: 273 فیلتر نتایج به سال:
Trauma is a major public health problem worldwide. Infectious complications, sepsis, and multiple organ dysfunction syndrome (MODS) remain important causes for morbidity and mortality in patients who survive the initial trauma. There is increasing evidence for the role of genetic variation in the innate immune system on infectious complications in severe trauma patients. We describe a trauma pa...
لکتین متصل شونده به مانوز (mbl) جزء خانواده کالکتین ها بوده و در فعال سازی سیستم کمپلمان ایمنی ذاتی از مسیر لکتین نقش دارد. mbl به عنوان اپسونین، فرآیند ذره خواری و حذف میکروارگانیسم بیگانه را تسهیل می کند. این پروتئین نقش مهمی در سلامت افراد دارد، به ویژه افرادی که دارای نقص سیستم ایمنی اولیه هستند، در صورتی که در پروتئین mbl هم نقص داشته باشند عوارض کلینیکی بیشتری را بروز می دهند. سلامت و صح...
INTRODUCTION Previous studies have provided inconsistent results on whether variants in the MBL2 gene, coding for the complement-activating mannan-binding lectin (MBL) protein, associate with rheumatoid arthritis (RA). We re-evaluated this in context of the main environmental and genetic risk factors (smoking, HLA-DRB1 'shared epitope' (SE), PTPN22*620W), which predispose to rheumatoid factor (...
BACKGROUND Mannose-binding lectin (MBL) is one of the key molecules in innate immunity and its role in human vaccine responses is poorly known. This study aimed to investigate the possible association of MBL polymorphisms with antibody production after primary and booster vaccinations with acellular pertussis vaccines in infants and adolescents. METHODOLOGY/PRINCIPAL FINDINGS Five hundred and...
Kawasaki disease (KD) is an acquired cardiac disease with a high incidence that affects children. KD has various complications, including coronary artery dilation (CAD) and coronary artery aneurysms (CAA). The identification of differentially expressed proteins and the underlying mechanisms may be the key to understanding differences between these KD complications. In the present study, isobari...
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