Taylor, Norman E., and Allen W. Cowley, Jr. Effect of renal medullary H2O2 on salt-induced hypertension and renal injury. Am J Physiol Regul Integr Comp Physiol 289: R1573–R1579, 2005. First published August 18, 2005; doi:10.1152/ajpregu.00525.2005.—Dahl salt-sensitive (SS) and consomic, salt-resistant SS-13 rats possess substantial differences in blood pressure salt-sensitivity even with highl...

A sensitive tissue-print assay for the detection and histological localization of H2O2 in freshly cut organ sections was developed by impregnating nitrocellulose paper with a mixture of Kl and soluble starch. H2O2 transferred from the cut surface of the section to the dried paper forms I2, which can be visualized by the intensely colored I2-starch complex. The detection limit of the assay is in...

degradation of acrylic water base color from synthetic wastewater by the fenton process was performed. experiments were conducted on the sample containing 100 and 400 mg/l of acrylic water base color. the study was performed for searching optimum values of feso4 and h2o2 concentration, ph and temperature. the h2o2 requirement seems to be related to initial cod of the sample. feso4/ h2o2 ratios ...

degradation of acrylic water base color from synthetic wastewater by the fenton process was performed. experiments were conducted on the sample containing 100 and 400 mg/l of acrylic water base color. the study was performed for searching optimum values of feso4 and h2o2 concentration, ph and temperature. the h2o2 requirement seems to be related to initial cod of the sample. feso4/ h2o2 ratios ...

Hydrogen peroxide (H2O2) perfused into the aorta of the isolated rat heart induces a positive inotropic effect, with cardiac arrhythmia such as extrasystolic potentiation or cardiac contractures, depending on the dose. The last effect is similar to the "stone heart" observed in reperfusion injury and may be ascribed to lipoperoxidation (LPO) of the membrane lipids, to protein damage, to reducti...

A membrane-permeable SOD mimetic, 4-hydroxytetramethyl-piperidine-1-oxyl (tempol), has been used as an antioxidant to prevent hypertension. We recently found that this SOD mimetic could not prevent development of hypertension induced by inhibition of renal medullary SOD with diethyldithiocarbamic acid. The present study tested a hypothesis that increased H2O2 counteracts the effects of tempol o...

Safingol, a L-threo-dihydrosphingosine, induced the nuclear translocation of a mitochondrial apoptogenic mediator--endonuclease G (endo G)--and apoptosis of human oral squamous cell carcinoma (SCC) cells. Upstream mediators remain largely unknown. The levels of hydrogen peroxide (H2O2) in cultured oral SCC cells were measured. Treatment with safingol increased intracellular H2O2 levels but not ...

Butylated hydroxyanisole (BHA) is a synthetic phenolic compound consisting of a mixture of two isomeric organic compounds: 2-tert-butyl-4-hydroxyanisole and 3-tert-butyl-4-hydroxyanisole. We examined the effect of BHA against hydrogen peroxide (H2O2)-induced apoptosis in primary cultured mouse hepatocytes. Cell viability was significantly decreased by H2O2 in a dose-dependent manner. Additional...