One proposed mechanism of cellular aging is the gradual loss of certain cellular components that are insufficiently renewed. In an earlier study, multidrug resistance transporters (MDRs) were postulated to be such aging determinants during the yeast replicative life span (RLS). Aged MDR proteins were asymmetrically retained by the aging mother cell and did not diffuse freely into the bud, where...

Abstract Background The 20 pole PentaRay Mapping Catheter is a high-definition mapping catheter with five soft, flexible spines providing better and faster acquisition. Despite its design, the not without glitches. Objective We queried Food Drug Administration Manufacturer User Facility Device Experience (MAUDE) database for adverse events related to use of catheter. Methods was searched report...

Development of antimicrobial resistance imposes a serious threat to the timely and efficient healing mankind who fall prey infectious agents. It is increasingly being reported day by throughout world. Irrational overuse antibiotics coupled with unavailability regional or local antibiogram aggravates situation further. To understand present antbiogram data for this region bridge existing knowled...

Introduction Isolated, confined, and extreme (ICE) environments such as found at Antarctic, Arctic, other remote research stations are considered space-analogs to study the long duration isolation aspects of operational space mission conditions. Methods We interviewed 24 sojourners that participated in different short/long missions an Antarctic (Concordia, Halley VI, Rothera, Neumayer II) or no...

Background: Milk is a reservoir for several groups of microorganisms, which may pose health risks. The aim of this work was to assess the antibiotic resistance and biofilm production in catalase-positive Gram-positive cocci isolated from Brazilian pasteurized milk. Methods: The bacteria were isolated using Baird-Parker agar and identified by Matrix-Assisted Laser Desorption/Ionization-Time-Of-...

OBJECTIVES Accurate methods of estimating HIV-1 incidence are critical for monitoring the status of the epidemic and the impact of prevention strategies. Although several laboratory-based tests have been developed strictly for this purpose, several limitations exist and improved methods or technologies are needed. We sought to further optimize a previously described bead-based, HIV-1-specific m...

OBJECTIVE To assess the utility of cost-effective dried blood spot (DBS) field sampling for incidence and drug resistance surveillance of persons at high risk for HIV infection. METHODS We evaluated DBS collected in 2007-2010 in non-clinical settings by finger-stick from HIV-positive heterosexuals at increased risk of HIV infection (n = 124), men who have sex with men (MSM, n = 110), and pers...

BACKGROUND In Thailand, the combined generic anti-retroviral drug stavudine/lamivudine/nevirapine (d4T/3TC/NVP) has been used to treat human immunodeficiency virus (HIV)-infected individuals since 2001. Due to relatively frequent adverse effects, d4T gradually has been replaced with tenofovir disoproxil fumarate (TDF). Although the frequency of adverse drug effects with TDF is lower than that w...

OBJECTIVE Alzheimer's disease (AD) is a devastating neurological disease characterized by pathological proteolytic cleavage of tau protein, which appears to initiate death of the neurons. The objective of this study was to investigate whether a proteolytic fragment of the tau protein could serve as blood-based biomarker of cognitive function in AD. METHODS We developed a highly sensitive ELIS...