Manoeuvring flight in animals requires precise adjustments of mechanical power output produced by the flight musculature. In many insects such as fruit flies, power generation is most likely varied by altering stretch-activated tension, that is set by sarcoplasmic calcium levels. The muscles reside in a thoracic shell that simultaneously drives both wings during wing flapping. Using a genetical...

Tubular mechanical stretch is the key primary insult in obstructive nephropathy. This review addresses how the renal tubular epithelium senses and responds to mechanical stretch. Using data from renal and nonrenal systems, we describe how sensing of stretch initially occurs via the activation of ion channels and subsequent increases in intracellular calcium levels. Calcium influxes activate a n...

objectives: major depression and anxiety disorders are common psychiatric disorders among cancer patients and are associated with psychosocial impairment and decreased quality of life. depressed and anxious cancer patients also experience a more rapid progression of cancer symptoms, increased mortality, more metastasis and pain, and increased medical utilization. although some research has expl...