This paper presents a new univariate decomposition method for design sensitivity analysis and reliabilitybased design optimization of mechanical systems subject to uncertain performance functions in constraints. The method involves a novel univariate approximation of a general multivariate function in the rotated Gaussian space for reliability analysis, analytical sensitivity of failure probabi...

Sensory systems can adapt to different environmental signals. Here we identify four conditions that modulate anterior touch sensitivity in Caenorhabditis elegans after several hours and demonstrate that such sensory modulation is integrated at multiple levels to produce a single output. Prolonged vibration involving integrin signaling directly sensitizes the touch receptor neurons (TRNs). In co...

Low-temperature magnetic properties of condensed matter system is investigated microscopically with high-frequency electron spin resonance (ESR). Experiments are carried out conventionally with a transmission method, but its sensitivity is not often sufficient to detect ESR signals of systems with small number of spins such as newly synthesized microcrystals. To attain better sensitivity, we fo...

Neurotrophins are important for the development and maintenance of both high and low threshold mechanoreceptors (HTMRs and LTMRs). In this series of studies, the effects of constitutive overexpression of two different neurotrophins, neurotrophin-3 (NT-3) and glial cell line derived neurotrohic factor (GDNF), were examined. Previous studies indicated that both of them may be implicated in the no...

This paper describes our views on how to detect faults in low testability analog or mixed mode (analog electro-mechanical) system. A new method is developed to identify a minimum number of faulty parameters in the system with ambiguities. From sensitivity analysis of the system, we can extract solution invariant matrix and identify singular cofactors of this matrix. The approach can be extended...

The interaction of a gravitational wave with a system made of an RLC circuit forming one end of a mechanical harmonic oscillator is investigated. We show that, in some configurations, the coherent interaction of the wave with both the mechanical oscillator and the RLC circuit gives rise to a mechanical quality factor increase of the electromagnetic signal. When this system is used as an amplifi...

We provide a quantum analysis of a dc SQUID mechanical displacement detector within the subcritical Josephson current regime. A segment of the SQUID loop forms the mechanical resonator and motion of the latter is transduced inductively through changes in the flux threading the loop. Expressions are derived for the detector signal response and noise, which are used to evaluate the position and f...

There is much evidence supporting the hypothesis that magnitude of nerve root mechanical injury affects the nature of the physiological responses which can contribute to pain in lumbar radiculopathy. Specifically, injury magnitude has been shown to modulate behavioral hypersensitivity responses in animal models of radiculopathy. However, no study has determined the mechanical deformation thresh...

This paper presents the design of a mechanical transducer for a new kind of optical-fiber accelerometer based on birefringence variation. Vibration-induced fiber deformation modifies the birefringence within the fiber and hence the state of polarization of the light. To deform the fiber a mechanical transducer has to be made. This article compares analytically different transducers using either...

Citation for published version (APA): Fernandez-de-las-Penas, C. (2012). Clinical evidence of generalised mechanical hypersensitivity in local musculoskeletal pain syndromes and headaches. General rights Copyright and moral rights for the publications made accessible in the public portal are retained by the authors and/or other copyright owners and it is a condition of accessing publications th...