Studies on cell fusion-mediated nuclear reprogramming have led to the breakthrough of the induced pluripotent stem (iPS) cell technology. While this technology has neared stem cells to applications more than any other method, the mechanistic bases of reprogramming remain largely unsolved. In this context, comparative studies of oocyte and cell fusion-mediated reprogramming hold the greatest pro...

In the Mechanistic–Empirical Pavement Design Guide (MEPDG), dynamic modulus of asphalt mixes is used as one of the input parameters in pavement analysis and design. For in-service pavements, MEPDG method uses a combination of some field and laboratory tests for structural evaluation of asphalt layers in rehabilitation projects. In this study, ten new and rehabilitated in-service asphalt pavemen...

In this study we introduce a mechanistic framework for modeling host-parasite coevolution using a nested modeling approach. The first step in this approach is to construct a mechanistic model of the parasite population dynamics within a host. The second step is to define an epidemiological model which is used to derive the fitness functions for both the host and the parasite. The within-host mo...

Many model based scientific and engineering methodologies, such as system identification, sensitivity analysis, optimization and control, require a large number of model evaluations. In particular, model based real-time control of urban water infrastructures and online flood alarm systems require fast prediction of the network response at different actuation and/or parameter values. General pur...

The urban wastewater system components (sewer, treatment plant, and river) are often modelled using complex mechanistic models. Mechanistic surrogate models are introduced here as simplified models that still contain some physical knowledge. Surrogate models are faster, but are less but still sufficiently accurate, and require more data to be calibrated. The possibilities of replacing actual fi...

An enantioselective iodolactonization reaction of allenoic acids has been developed using a trisimidazoline catalyst and I2. Our mechanistic study suggests the involvement of a π-allyl cation intermediate in this reaction system.

In conclusion, our work expands our understanding of tumor progression and provides further mechanistic rationale to develop novel interventions targeting immunosuppression. Future studies should unveil other unrecognized aspects of the contribution of the immune system to cancer prevention and progression.

We provide a taxonomy of the two most important debates in the philosophy of the cognitive and neural sciences. The first debate is over methodological individualism: is the object of the cognitive and neural sciences the brain, the whole animal, or the animal--environment system? The second is over explanatory style: should explanation in cognitive and neural science be reductionist-mechanisti...

This study explored the feasibility of lignin based biofuel co-product (BCP) for subgrade soil stabilization, and more specifically, its impact on Hot-Mix Asphalt (HMA) pavement performance using the Mechanistic-Empirical Pavement Design Guide (MEPDG). The HMA pavement systems with BCP stabilized subgrade under different traffic and climate conditions were modeled using mechanistic based damage...