The scotogenic model is the Standard Model (SM) with Z2 symmetry and addition of odd right-handed Majorana neutrinos SU(2)L doublet scalar fields. We have extended original by an additional singlet field that plays a role in dark matter. In our model, asymmetries lepton are simultaneously produced through CP-violating neutrino decays. While former converted into baryon asymmetry sphaleron proce...

Mediator complexes (MED) link transcriptional regulators to RNA polymerase II. Here, we summarize the latest advances on the functional organization of yeast Mediator. We argue for the existence of a "universal" Mediator structurally conserved from yeast to man, based on an extensive analysis of sequence databases. Finally, we examine the implications of these observations for the physiological...

Serum samples from patients with many different kinds of infection were shown to contain a substance characteristic of leukocytic endogenous mediator. Generalized bacterial infections produced more leukocytic endogenous mediator than did localized ones; viral infections produced very little. In typhoid fever, mediator concentrations increased before the onset of illness.

BACKGROUND Mediation analysis is useful for understanding mechanisms and has been used minimally in the study of the environment and disease. OBJECTIVE We examined mediation of the association between phthalate exposure during pregnancy and preterm birth by oxidative stress. METHODS This nested case-control study of preterm birth (n = 130 cases, 352 controls) included women who delivered in...

Finding a feasible protocol for probing the quantum nature of gravity has been attracting an increasing amount attention. In this manuscript, we propose to enhance detection gravitationally induced entanglement by exploiting two-phonon drive in hybrid setup. We consider setup consisting test particle double-well potential, qubit and mediator. There is gravitational interaction between mediator,...

This paper investigates communication between an informed expert and an uninformed principal via a strategic mediator. We demonstrate that, for any bias in the parties’preferences, there exists a strategic mediator that provides the highest expected payo¤ to the principal, as if the players had communicated through an optimal non-strategic mediator. JEL classi…cation: C72, D82, D83

Upon pathogen infection, plants undergo dramatic transcriptome reprogramming to shift from normal growth and development to immune response. During this rapid process, the multiprotein Mediator complex has been recognized as an important player to fine-tune gene-specific and pathway-specific transcriptional reprogramming by acting as an adaptor/coregulator between sequence-specific transcriptio...

This article presents marginal structural models with inverse propensity weighting (IPW) for assessing mediation. Generally, individuals are not randomly assigned to levels of the mediator. Therefore, confounders of the mediator and outcome may exist that limit causal inferences, a goal of mediation analysis. Either regression adjustment or IPW can be used to take confounding into account, but ...

In this report, data are presented on the regulation of MHC class II antigen expression by a mediator present in supernatants of human mixed leukocyte cultures (MLC-SN), and which is different from IFN-gamma. The capacity of supernatants to induce antigen expression did not correspond to titers of IFN-gamma. Removal of IFN-gamma using either dialysis against pH 2 or neutralizing mAb against hum...