In a yeast two-hybrid screen for cellular factors that could interact with human immunodeficiency virus type 1 (HIV-1) Gag protein, we identified PDZD8 and confirmed the interaction by coimmunoprecipitation (co-IP). PDZD8 overexpression promoted the initiation of reverse transcription and increased infection by pseudotyped retroviruses independent of the route of viral entry, while transient kn...

aim and background: schemas are cognitive patterns that have a major impact on the perception and behavior. therefore, it is necessary to investigate their role in determining and changing health related behaviors in ms patients. the purpose of this study is to investigate the mediating effect of illness perception on the relationship between early maladaptive schemas in the domain of rejection...

The 26-subunit, 1.2 MDa human Mediator complex is essential for expression of perhaps all protein-coding genes. Activator binding triggers major structural shifts within Mediator, suggesting a straightforward means to spatially and temporally regulate Mediator activity. By using mass spectrometry (MudPIT) and other techniques, we have compared the subunit composition of Mediator in three differ...

Introduction. The goal of domain ontology is to provide a common conceptual vocabulary to members of a virtual community of users who need to share their information in a particular domain (such as medical, tourism, banking, agricultural). The identification and definition of concepts that describe the domain knowledge requires a certain consensus. Generally, each member or subcommunity holds s...

Accessing knowledge of a single knowledge source with different client applications often requires the help of mediator systems as middleware components. In the domain of theorem proving large efforts have been made to formalize knowledge for mathematics and verification issues, and to structure it in databases. But these databases are either specialized for a single client, or if the knowledge...

In this work, we describe the set of tools comprising the Data Access Infrastructure within Advancing Clinico-genomic Trials on Cancer (ACGT), a R&D Project funded in part by the European. This infrastructure aims at improving Post-genomic clinical trials by providing seamless access to integrated clinical, genetic, and image databases. A data access layer, based on OGSA-DAI, has been developed...

Dynamically providing students with clear explanations of complex spatial concepts is critical for a broad range of knowledge-based educational and training systems. This calls for a realtime solution that can dynamically create 3D animated explanations that artfully integrate well-chosen speech. We present a visuo-linguistic framework for generating multimedia spatial explanations combining 3D...

Smad proteins mediate transforming growth factor beta signaling from the cell membrane to the nucleus. Upon phosphorylation by the activated receptor kinases, the receptor-regulated Smad, such as Smad2, forms a heterocomplex with the co-mediator Smad, Smad4. This heterocomplex is then translocated into the nucleus, where it associates with other transcription factors and regulates expression of...

Tat-interactive protein 60 (Tip60) is a MYST histone acetyltransferase that catalyses acetylation of the major DNA damage kinase Ataxia telangiectasia mutated (ATM), thereby triggering cellular signalling required for the maintenance of genomic stability on genotoxic insults. The Tip60 activity is modulated by post-translational modifications that alter its stability and its interactions with s...