ii ACKNOWLEDGEMENTS I would like to take this opportunity to thank Dr. Mitch Wilkes, the chairman of my Ph.D committee, for being so supportive of my academic goals and for being so kind to provide me with the protected academic time and financial aid to pursue these goals. As my advisor and mentor, he has shown me what a good professor should be. I am also grateful to all of those whom I have ...

Operative role management relates to delegating the right roles to the right resources at a specific moment. Role management is commonly understood as technical role management, relating to access control and administrative role management. Operative role management is the practical daily work of emergency organizations’ personnel and relates to overall resource management. The authors have car...

The role of the genetically polymorphic CYP3A5 in the metabolism of CYP3A substrates is unclear. We investigated the contributions of the CYP3A4 and CYP3A5 isoforms to the metabolism of the phosphodiesterase type 5 inhibitors (PDE5Is) sildenafil, udenafil, and vardenafil. In vitro incubation studies of sildenafil N-demethylation, udenafil N-dealkylation, and vardenafil N-deethylation were condu...

The role of the genetically polymorphic CYP3A5 in the metabolism of CYP3A substrates is unclear. We investigated the contributions of the CYP3A4 and CYP3A5 isoforms to the metabolism of the phosphodiesterase type 5 inhibitors (PDE5Is) sildenafil, udenafil, and vardenafil. In vitro incubation studies of sildenafil N-demethylation, udenafil N-dealkylation, and vardenafil N-deethylation were condu...

This paper focuses on the methodology used in applying the Time Series Data Mining techniques to financial time series data for calculating currency exchange rates of US dollars to Indian Rupees. Four Models namely Multiple Regression in Excel, Multiple Linear Regression of Dedicated Time Series Analysis in Weka, Vector Autoregressive Model in R and Neural Network Model using NeuralWorks Predic...

This master’s thesis concerns the implementation of a GPUaccelerated version of Mehrotra’s predictor-corrector interior point algorithm for large-scale linear programming (LP). The implementations are tested on LP problems arising in the financial industry, where there is high demand for faster LP solvers. The algorithm was implemented in C++, MATLAB and CUDA, using double precision for numeric...

Interior point method (IPM) defines a search direction at each interior point of a region. These search directions form a direction field which in turn gives rise to a system of ordinary differential equations (ODEs). The solutions of the system of ODEs can be viewed as underlying paths in the interior of the region. In [31], these off-central paths are shown to be well-defined analytic curves ...

The estimated number of Asian Americans (AA), Native Hawaiians (NH), and Pacific Islanders (PI) in the United States is 23.0 million (7.5%); AA (7.0%) and NH and PI (0.5%), respectively (U.S. Census Bureau, 2016a). AA are persons with ancestry from Asian countries and islands in the Pacific Rim Basin, and the largest AA populations are Chinese (4.8 million), Asian Indian (4.1 million), Filipino...

8 Felsenfeld, G., and S. Huang, Biochim. Biophys. Acta, 51, 19 (1961). 9 Lyons, J. W., and L. Kotin, J. Am. Chem. Soc., 86, 3634 (1964). 10 Boedtker, H., J. Mol. Biol., 2, 171 (1960). 11 Monier, R., and M. Grunberg-Manago, in Acides Ribonucleiques et Polyphosphates, Colloques Internationaux de Centre National du la Recherche Scientifique no. 106 (Paris, 1962), p. 163. 12 Giacomoni, D., and S. S...

Sir, with great interest, we read the article by Schoonman et al. (2008), who claim that ‘in contrast to widespread belief, migraine attacks are not associated with vasodilatation of cerebral or meningeal blood vessels’ and, therefore, ‘future anti-migraine agents may not require vasoconstrictor action’. Whereas the methodology used in this investigation is elegant, we disagree with their claim...