Melaleuca (Melaleuca alternifolia) essential oil (MEO), commonly known as tea tree oil, is popularly used in skincare products. In the current study, we investigated the biological activity of a commercially available MEO (with terpinen-4-ol as the major active component) in pre-inflamed human dermal fibroblasts, which were designed to simulate chronic inflammation. We analyzed the levels of se...

RESUMO A madeira trata-se de uma matéria-prima fonte renovável amplamente utilizada pelo setor da construção civil devido às suas características fácil manuseio e processabilidade, boas propriedades mecânicas, sustentabilidade, entre outros. Por se tratar um material origem vegetal faz-se necessário a realização tratamento preservativo antes sua aplicação na civil. Neste contexto, busca novas s...

The invasive treeMelaleuca quinquenervia (Cav.) Blake is widely distributed throughout peninsular Florida and poses a signiÞcant threat to species diversity in the wetland systems of the Everglades. Mitigation of this threat includes the areawide release campaign of the biological control agentsOxyops vitiosa Pascoe and Boreioglycaspis melaleucaeMoore. We summarize the results of this release e...

AIMS To investigate the in vitro antifungal activity of the components of Melaleuca alternifolia (tea tree) oil. METHODS AND RESULTS Activity was investigated by broth microdilution and macrodilution, and time kill methods. Components showing the most activity, with minimum inhibitory concentrations and minimum fungicidal concentrations of < or =0.25%, were terpinen-4-ol, alpha-terpineol, lin...

The aim of this study was to evaluate the activity of fluconazole against 32 clinical strains of fluconazole-resistant Candida albicans, and C. albicans ATCC 10231 reference strain, after their exposure to sublethal concentrations of tea tree oil (TTO) or its main bioactive component terpinen-4-ol. For all tested fluconazole-resistant C. albicans strains TTO and terpinen-4-ol minimal inhibitory...

BACKGROUND There are several synergistic methods available. However, there is a vast discrepancy in the interpretation of the synergistic results. Also, these synergistic methods do not assess the influence the tested components (drugs, plant and natural extracts), have upon one another, when more than two components are combined. METHODS A modified checkerboard method was used to evaluate th...