AIM To explore whether disparities exist in melanoma incidence and prognosis between White Hispanics and White non-Hispanics. METHODS Analyses were based on 42,770 patients with malignant melanoma in the United States, 2004 through 2006. RESULTS Hispanics were significantly less likely to be diagnosed with superficial spreading melanoma or Hutchinson's melanotic freckle, but significantly m...

Purpose:Certain clinicopathologic features correlate with BRAFmutation status inmelanoma including younger age and primary subtype. This study sought to determine the BRAFmutation status by age-decade and whether BRAF-mutant genotypes correlated with clinicopathologic features and outcome in patients with metastatic melanoma. Methods: A prospectively assembled cohort of Australian patients were...

BACKGROUND Population-based data on melanoma survival are important for understanding the impact of demographic and clinical factors on prognosis. OBJECTIVE We describe melanoma survival by age, sex, race/ethnicity, stage, depth, histology, and site. METHODS Using Surveillance, Epidemiology, and End Results data, we calculated unadjusted cause-specific survival up to 10 years from diagnosis...

The diagnosis of seborrheic keratosis is a clinical diagnosis. In a certain percentage of cases, differential diagnosis between seborrheic keratosis and malignant melanoma is difficult. We describe a case of regressing seborrheic keratosis simulating malignant melanoma. Clinical, dermoscopic and histopathologic examinations were performed for the occurrence of an asymmetric, irregularly demarca...

Malignant melanoma predominantly occurs in the skin and mucous membranes, thus, malignant melanoma of the breast is particularly rare. In the current study, a case of a 26-year-old female with a malignant melanoma of the breast is presented. On diagnosis of the patient, extensive metastasis had occurred. The patient refused any treatment and succumbed two months after the initial diagnosis. The...

Primary rectal melanoma is rare and only represents up to 4% of anorectal malignancies. The prognosis of such a diagnosis is significantly different to a metastatic melanoma deposit in the anorectal area and therefore differentiation between the two is of the utmost importance with regards to initial treatment and long-term management. Various immunohistochemical markers have been shown to be a...

BACKGROUND Primary melanoma of the small bowel is extremely rare. Only a limited number of cases have been described in the literature. Mostly, the small intestine is affected by metastatic tumors of other primary lesions, especially cutaneous. CASE PRESENTATION We report the case of a 75-year-old North African woman with a small bowel melanoma. The diagnosis was made by histological examinat...

We report a case of dermal malignant melanoma that stained negatively for commonly done immunostains, HMB-45, and Melan-A. It stained weakly positive for S-100 protein, a less specific marker for melanocytes. The diagnosis was established by strongly positive immunostaining by MITF ( microphthlmia-associated transcription factor). A brief review of the MITF and its usefulness in the diagnosis o...

Prompt diagnosis is the most reliable solution for an effective treatment of melanoma. There is an ongoing research for providing computer-aided imaging tools in order to support the early detection and diagnosis of malignant melanomas. The first step towards producing such a diagnosis system is the automated and accurate boundary detection of skin lesion. Therefore, the present study introduce...

BACKGROUND A retrospective study was conducted to review the overall survival and treatment outcomes of high grade melanoma in the extremity to explore the clinical features of malignant melanoma of the hand and foot, and the therapeutic efficacies and survival rate after amputation. METHODS The clinical data of 30 patients with malignant melanoma of the hand and foot (confirmed by pathologic...