نتایج جستجو برای: melatonin ischemiareperfusion
تعداد نتایج: 10970 فیلتر نتایج به سال:
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Background : The Obesity and metabolic diseases appears to have emerged largely and epidemically because of changes in our diet and life style. The aim of this study was to investigate the effects of melatoninon plasma glucose, uric acid, insulin, HOMA, body weight gain and Liver and kidney histology in fructose fed rats. Methods: In this experimental study, 24 male Wistar rats were used. A...
background: damage to spermatogenic and fertility disorders are among major side effects of chemotography drugs such as busulfan. to reduce the side effects of these drugs different methods such as protecting and fixing germinal cell epithelium, while employing chemotherapy are used. the aim of this study was to investigate the effect of exogenous melatonin on the treatment of oligospermic in s...
Influence of oxidative stress on oocyte quality and protective role of melatonin as an antioxida Poor oocyte quality is an important cause of female infertility. Reactive oxygen species (ROS) are produced within ovarian follicles, especially during ovulation process, and it is thought that increased ROS activity may be a cause of impaired oocyte maturation. Pineal hormone, melatonin, is detecte...
Melatonin (N-acetyl-5-methoxytryptamine) is a highly conserved molecule that is not exclusive to the animal kingdom and its presence in plants has been confirmed by numerous studies. Melatonin has delayed flowering in some day-sensitive plants. When spinach enters the reproduction phase, its nutritional value is markedly reduced. This experiment was conducted to evaluate the effects of melatoni...
Background: Neuroinflammation and oxidative stress play a pivotal role in the diabetic neuropathic pain. The aim of this study was to evaluate the effect of aerobic exercise with melatonin on RAGE gene expression and some indicators of oxidative stress in rats with diabetic neuropathic pain Methods: Forty 8-week-old male Wistar rats (weight range 204 ± 11.3 g) were randomly divided into five o...
Background: Peripheral nerve injury (PNI) is a common condition that compromises motor and sensory functions. Peripheral nerves are known to have regenerative capability and the pineal hormone, melatonin, is known to aid nerve regeneration. However, the role of Schwann cells and the pathways involved remain unclear. Thus, the aim of this study is to identify the effects of melatonin on Schwann ...
Cholangiocarcinoma (CCA) is a devastating biliary cancer. Melatonin is synthesized in the pineal gland and peripheral organs from serotonin by two enzymes, serotonin N-acetyltransferase (AANAT) and acetylserotonin O-methyltransferase (ASMT). Cholangiocytes secrete neuroendocrine factors, including serotonin-regulating CCA growth by autocrine mechanisms. Melatonin exerts its effects by interacti...
BACKGROUND Previous studies have suggested that melatonin may produce antinociception through peripheral and central mechanisms. Based on the preliminary encouraging results of studies of the effects of melatonin on pain modulation, the important question has been raised of whether there is a dose relationship in humans of melatonin on pain modulation. OBJECTIVE The objective was to evaluate ...
The pineal hormone melatonin regulates testicular function through the hypothalamic-adenohypophyseal axis. In addition, direct actions of melatonin in somatic cells of the testis have been described. Melatonin acts as a local modulator of the endocrine activity in Leydig cells. In Sertoli cells, melatonin influences cellular growth, proliferation, energy metabolism and the oxidation state, and ...
The ovine pars tuberalis (PT) still offers the best model for the study of signal transduction pathways regulated by the melatonin receptor. From the evidence accumulated so far, it seems likely that the cAMP signal transduction pathway will be a major effector of a stimulatory signal to the PT which can be regulated by melatonin. Thus a principal action of melatonin in the PT may be the repres...
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