The precise pathways of memory T-cell differentiation are incompletely understood. Here we exploit transgenic mice expressing fluorescent cell cycle indicators to longitudinally track the division dynamics of individual CD8(+) T cells. During influenza virus infection in vivo, naive T cells enter a CD62L(intermediate) state of fast proliferation, which continues for at least nine generations. A...

Nootropics or smart drugs are well-known compounds or supplements that enhance the cognitive performance. They work by increasing the mental function such as memory, creativity, motivation, and attention. Recent researches were focused on establishing a new potential nootropic derived from synthetic and natural products. The influence of nootropic in the brain has been studied widely. The nootr...

objective(s): there is controversial evidence about the effect of methamphetamine (meth) on spatial memory. we tested the time- dependent effects of meth on spatial short-term (working) and long-term (reference) memory in meth –sensitized and withdrawn rats in the morris water maze. materials and methods: rats were sensitized to meth (2 mg/kg, daily/5 days, sc). rats were trained in water maze ...

abstract aim and background: evaluation of cognition is fundamental for every comprehensive epilepsy program. we sought to conduct this study to assess memory state of patients with refractory temporal lobe epilepsy before decision for epilepsy surgery. method and materials: in a case-control study, 20 patients with right temporal lobe epilepsy and 20 patients with left temporal lobe epilepsy w...

Individual susceptibility determines the magnitude of stress effects on cognitive function. The hippocampus, a brain region of memory consolidation, is vulnerable to stressful environments, and the impact of stress on hippocampus may determine individual variability in cognitive performance. Therefore, the purpose of this study was to define the relationship between the divergence in spatial me...

Immunological memory is a fundamental function of vaccination. The antigenic breakdown products of the vaccine may not persist, and undefined tonic stimulation has been proposed to maintain the specific memory. We have suggested that cellular stress agents to which the immune cells are constantly exposed may be responsible for tonic stimulation. Here we have studied four stress agents: sodium a...

background and aim: today, bilingualism is a developing phenomenon which half of the world population is bilingual. auditory system is the main route to language learning, so it is expected that bilingualism has an effect on functions of the auditory system. auditory memory is one of the auditory processes which is a cornerstone of linguistic skills and learning process growth, so that, it has ...

bile duct ligation (bdl) is shown to induce cholestasis-related liver function impairments as well as consequent cognitive dysfunctions (i.e. impaired learning and memory formation). this study investigates the effects of cholestasis (14, 21 and 28 days post bile duct ligation) on spatial and non-spatial novelty detection, using a non-associative task. male mice weighing 30-35 g were used. chol...

Long-lasting long-term potentiation (L-LTP) is a cellular mechanism of learning and memory storage. Studies have demonstrated requirement for extracellular signal-regulated kinase (ERK) activation in L-LTP produced by diversity temporal stimulation patterns. Multiple signaling pathways converge to activate ERK, with different being required To answer whether how patterns select ERK activation, ...

objectives: the prospective and retrospective memory questionnaire (prmq) developed by smith (2000) and consists of a series of questions about memory weakness that can be encountered anyone in everyday life. the self-reported questionnaire has 16 items that assessing of prospective and retrospective memory problems in everyday life and the aim of the present research was to examine the investi...