background: although the pathogenesis of diabetes type 1 (t1d) is not fully elucidated. different clusters of lymphocytes such as cd4+ and cd8+ t cells are involved in it. moreover, the mechanism of how stem-cell therapy results in significant therapeutic outcomes in diabetes remains obscure. in the current study, we aimed to analyze lymphocyte subsets in patients with t1d before and after trea...

THE BRAZILIAN SOCIETY FOR BLOOD AND MARROW TRANSPLANTATION (SBTMO) PRESENTS GUIDELINES ON HEMATOPOIETIC STEM CELL

Menstrual-derived stem cells (MenSCs) are a new source of mesenchymal stem cells isolated from the menstrual fluid. Currently, there is a growing interest in their clinical potential due to fact that they are multipotent, highly proliferative, and easy to obtain in a non-invasive manner. Sampling can be repeated periodically in a simplified and reproducible manner devoid of complications that n...

Background: Endometriosis is a gynecological disease associated with severe pelvic pain and infertility. Immunological changes that occur in patients with endometriosis include reduced natural killer cell and T-lymphocyte cytotoxicity in the peritoneal fluid, and an elevated number of activated macrophages. MIF via its receptor, CD74, initiates a signaling cascade that leads to proliferation an...

the clinical potentials of stem cells in cell-based therapies have raised great hopes in diabetes mellitus as well. however, there are complex ethical, legal, and socio-cultural issues surrounding the subject. in this paper, we intend to review in brief the main ethical issues for endocrinologists and other clinicians who are interested and work in the field of cell therapy and research.

Survival of patients with multiple myeloma has improved substantially because of availability of new therapies including autotransplants, immunomodulating drugs and proteasome-inhibitors. Second primary cancers have emerged as an important determinant of morbidity and mortality among cancer survivors. Even though there is an increased risk of new cancers of the lymphoreticular and haematopoetic...

A large number of myocytes are necessary to treat intractable muscular disorders such as Duchenne muscular dystrophy with cell-based therapies. However, starting materials for cellular therapy products such as myoblasts, marrow stromal cells, menstrual blood-derived cells, and placenta-derived cells have a limited lifespan and cease to proliferate in vitro. From the viewpoints of manufacturing ...

introduction: cardiac glycosides such as digoxin or digitoxin are the natural products that are traditionally used to increase cardiac contractile force in patients with heart failure and cardiac arrhythmias. it has been shown that digoxin can directly inhibit the cell proliferation and lead to cell apoptosis. present study was conducted to analyze the effect of digoxin in the cohorts of mesenc...