The term psychogenomics is used here to describe the process of applying the powerful tools of genomics and proteomics to achieve a better understanding of the biological substrates of normal behavior and of diseases of the brain that manifest themselves as behavioral abnormalities. Applying psychogenomics to the study of drug addiction will lead to the identification of genes and their protein...

Dispersal and recruitment are fundamental processes for population recovery following disturbances in sessile species. While both processes are well understood for many terrestrial species, they still remain poorly resolved for some macroalgal species. Here we experimentally investigated the effective dispersal and recruit survival of a mesophotic Mediterranean fucoid, Cystoseira zosteroides. I...

Memory reconsolidation — the process by which memories can become destabilised at retrieval, and be updated or modified — offers a potential therapeutic opportunity for mental health disorders based upon maladaptive emotional memories, such as drug addiction. Blocking the reconsolidation of pavlovian cue-drug memories persistently reduces subsequent relapse in rodent models and in human experim...

OBJECTIVE To describe the characteristics at enrollment and outcomes of doctors in a substance dependence monitoring programme in Canada. DESIGN Prospective descriptive study. SETTING Provincial physician health programme, Canada. PARTICIPANTS All 100 doctors consecutively admitted to a substance dependence monitoring programme and followed until completion of monitoring or on leaving the...

The authors investigated the cue dependency of source and item memory. Individuals listened to words spoken by a man or a woman and later determined whether a test word was previously presented by a man or by a woman, or whether it was a new word. Cue dependent effects were assessed by presenting test words with (a) the same voice (match condition) that originally presented the word, (b) a diff...

OBJECTIVES To determine whether and to what extent cannabis dependence is associated with comorbid psychiatric disorders and specific stages of change in treatment-seeking patients. METHODS We evaluated 80 cannabis-dependent, treatment-seeking patients residing in an urban area. Data on cannabis dependence, psychiatric disorders, and motivation were obtained using the Schedules for Clinical A...

Despite the many similarities between nicotine dependence and other drug dependences, national guidelines for their treatment differ in several respects. The recent national guideline for the treatment of nicotine dependence has (i) less emphasis on detailed assessment; (ii) less emphasis on treatment of psychiatric comorbidity; (iii) less acceptance of reduction of use as an initial treatment ...

Only half of older adults with a mental disorder use mental health services, and little is known about the causes of perceived need for mental health care (MHC). We used logistic regression to examine relationships among depression, anxiety, chronic physical illness, alcohol abuse and/or dependence, sociodemographics, and perceived need among a national sample of community-dwelling individuals ...

s | 43 PS126 DAPK1 interaction with NMDA receptor NR2B subunit underlies the rapid antidepressant effect Ling-Zhi Xu,1,2,# Su-Xia Li,2,# Ying Han 1,2,#, Ruo-Xi Zhang,1,2 Lin Lu 1,2,3 1Institute of Mental Health/Peking University Sixth Hospital and Key Laboratory of Mental Health, Ministry of Health, Beijing, China; 2National Institute on Drug Dependence, Peking University, Beijing, China; 3Peki...

s | 43 PS126 DAPK1 interaction with NMDA receptor NR2B subunit underlies the rapid antidepressant effect Ling-Zhi Xu,1,2,# Su-Xia Li,2,# Ying Han 1,2,#, Ruo-Xi Zhang,1,2 Lin Lu 1,2,3 1Institute of Mental Health/Peking University Sixth Hospital and Key Laboratory of Mental Health, Ministry of Health, Beijing, China; 2National Institute on Drug Dependence, Peking University, Beijing, China; 3Peki...