Unlike other malignant bone tumors including osteosarcomas and Ewing sarcomas with a peak incidence in adolescents and young adults, conventional and dedifferentiated chondrosarcomas mainly affect people in the 4th to 7th decade of life. To date, the cell type of chondrosarcoma origin is not clearly defined. However, it seems that mesenchymal stem and progenitor cells (MSPC) in the bone marrow ...

Mesenchymal chondrosarcoma of the head and neck is an uncommon tumor with a potential for exhibiting highly aggressive behavior. When these tumors arise in the head and neck region, they appear to have a predilection for the maxillofacial skeleton; less often, they may involve other soft tissue sites in the head and neck. The diagnosis is challenging and may be assisted by molecular pathologic ...

MicroRNAs (miRs) can lead to mRNA degradation or inhibit protein translation through directly binding to the 3'-untranslational region (UTR) of their target mRNAs. Deregulation of miR-10b has been reported to be associated with chondrosarcoma. However, the role of miR-10b in chondrosarcoma cell migration and invasion, as well as the underlying mechanisms, has not been investigated. In the prese...