TO THE EDITOR: After decades of studies showing moderate aerobic exercise done during the mid-postprandial period improving blood glucose and triglycerides, it is gratifying to note that resistance exercise under similar conditions also offers similar results. Heden and colleagues (1) find resistance exercise at the 45-min postmeal mark more effective than premeal resistance exercise in lowerin...

Objective: To assess the degree of metabolic control and the presence of type 2 diabetes complications in diabetic immigrants. Methods: Cross-sectional case-control observational study, matched by age and sex. Cases: Hindustani diabetic immigrants (n= 116) and non-hindustani (n= 113). Controls: native diabetic patients with type 2 diabetes (n= 229). The relation male/female was 6.7, 0.8 y 2, re...

This is an expanded account of a talk on the mathematical aspects of Metabolic Control Analysis which I gave to the Theory Reading Group at the Bauer Centre on 30 September 2002.

objective: the aim of this study was to compare the quality of diet measured by healthy eating index (hei) between individuals with and without metabolic syndrome. materials and methods: this case-control study was performed in tehran and consisted of 103 overweight and obese individuals (52 cases and 51 controls) within age range of 20 to 55 years. case and control were matched for age and sex...

In this work, a novel optimization-based metabolic control analysis (OMCA) method is introduced for reducing data requirement for metabolic control analysis (MCA). It is postulated that using the optimal control approach, the fluxes in a metabolic network are correlated to metabolite concentrations and enzyme activities as a state-feedback control system that is optimal with respect to a homeos...

Zellweger syndrome and related disorders represent a group of lethal, genetically heterogeneous diseases. These peroxisome biogenesis disorders (PBDs) are characterized by defective peroxisomal matrix protein import and comprise at least 10 complementation groups. The genes defective in seven of these groups and more than 90% of PBD patients are now known. Here we examine the distribution of pe...

We study the effect of extrinsic noise in metabolic networks. We introduce external random fluctuations at the kinetic level, and show how these lead to a stochastic generalization of standard metabolic control analysis. While summation and connectivity theorems hold true in the presence of extrinsic noise, control coefficients incorporate its effect through an explicit dependency on the noise ...

Metabolic control analysis is a biochemical formalism defined by Kacser and Burns in 1973, and given firm mathematical basis by Reder in 1988. The algorithm defined by Reder for calculating the control matrices is still used by software programs today, but is only valid for some biochemical models. We show that, with slight modification, the algorithm may be applied to all models.

Deciphering the control principles of metabolism and its interaction with other cellular functions is central to biomedicine and biotechnology. Yet, understanding the efficient control of metabolic fluxes remains elusive for large-scale metabolic networks. Existing methods either require specifying a cellular objective or are limited to small networks due to computational complexity. Here we de...