نتایج جستجو برای: metabolically obese
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Obesity is considered a main factor contributing in diabetes mellitus development and a predictor of CV disease and events. Based on the Adult Treatment Panel-III criteria subjects with established obesity and co-existing other metabolic abnormalities including dyslipidemia, insulin resistance (IR), increased fasting glucose and impaired glucose tolerance, are referred metabolically unhealthy o...
Article history: Received 29 September 2015 Accepted 29 September 2015 Available online 15 October 2015 unclear which factorsmay play a role inmodification of healthy and unhealthy obesity phenotypes. Therefore, studying the relationship between lipid metabolism and the status of metabolically healthy or unhealthy obese individuals is of considerable interest. In this issue of EBioMedicine, Ni ...
RESULTSdCorrelates of the MHO (n = 454 [12.1%]) included smoking, socioeconomic disadvantage, and physical inactivity. Compared with metabolically healthy normal-weight subjects (n = 1,172 [31.3%]), theMHOweremore likely to developmetabolic risk (15.5 vs. 33.1%, P , 0.001) and incident diabetes (odds ratio 2.09 [95% CI 0.87–5.03]) but not CVD/stroke (1.16 [0.58–2.29]) during 5.5–10.3 years of f...
Adipose tissue macrophage (ATM)-driven inflammation plays a key role in insulin resistance; however, factors activating ATMs are poorly understood. Using a proteomics approach, we show that markers of classical activation are absent on ATMs from obese humans but are readily detectable on airway macrophages of patients with cystic fibrosis, a disease associated with chronic bacterial infection. ...
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