Bortezomib, a novel proteasome inhibitor approved for the treatment of cancer in adults, has recently been introduced in pediatric clinical trials. Any tissue-specific side effects on bone development have to our knowledge not yet been explored. To address this, we experimentally studied the effects of bortezomib in vivo in young mice and in vitro in organ cultures of rat metatarsal bones and h...

Trans-resveratrol (RES), naturally produced by many plants, has a structure similar to synthetic estrogen diethylstilbestrol, but any effect on bone growth has not yet been clarified. Pre-pubertal ovary-intact New Zealand white rabbits received daily oral administration of either vehicle (control) or RES (200 mg/kg) until growth plate fusion occurred. Bone growth and growth plate size were long...

Fig. 2 A 41-year-old man who suffered from pain in several joints for more than 10 years was referred for a bone scintigraphy. The patient was treated with non-steroidal anti-inflammatory drugs, but this treatment regimen did not result in a reduction of symptoms. Upon completion of the physical examination, no remarkable findings were noted. All routine laboratory tests were normal. The images...

Meningeal extramedullary hematopoiesis (EMH) is a rare finding in idiopathic myelofibrosis. Intracranial EMH is typically asymptomatic and sites are usually found by chance. Diagnosis of EMH is difficult, based on clinical circumstances and the use of different diagnostic imaging modalities, such as CT, MRI or radionuclide imaging. We present a case with intracranial medullary hematopoiesis due...

The lengths of the digital bones of the fore- and hind-limbs obtained post mortem from 40 cattle of different ages were measured using digital radiographs. The lengths of the individual digital bones and the overall length of the digit were determined using computer software. The lateral metacarpal/metatarsal condyle, and lateral P1 and P2 were significantly longer than their medial counterpart...

[Purpose] To report an adolescent male basketball player with nonhealing stress fractures of the foot and discuss the probable factors. [Subject and Methods] A 13-year-old basketball player presented with right foot pain. He had been playing basketball for three years and practicing 5 days/week. He denied any increase in daily training intensity. Magnetic resonance imaging confirmed stress frac...

In this study; it is aimed to present the operative treatment and results, which are indicated for continue of their racing life in splint bone fractures frequently occurred race horses. The 2nd 4th metacarpal (Mc-II Mc-IV) metatarsal bones (Mt-II Mt-IV) horse accessory structures that support carpus tarsus. Fractures these horses called “splint fractures”. Splint relatively common usually seen...

To evaluate the metatarsal head that was associated with highest plantar pressure after resection (MHR) and relations reulceration at one year, a prospective conducted total of sixty-five patients diabetes who suffered from first MHR an inactive ulcer moment inclusion. Peak time integral were recorded five specific locations in forefoot: first, second, third, fourth, fifth heads. The value four...