to evaluate the effectiveness of a relapse prevention cognitive-behavioral model, based on marlatt treatment approach, in opioid-dependent patients participating in the methadone maintenance treatment (mmt) in iran.the study consisted of 92 individuals treated with methadone in iranian national center of addiction studies (incas). participants were randomized into two groups: educational interv...

BACKGROUND This study aimed to investigate the initial dosage of methadone and factors affecting it in maintenance therapy. METHODS This cross-sectional, descriptive-analytic study was conducted on 157 individuals referring to a methadone maintenance therapy (MMT) clinic. The initial dosage of methadone was 20-45 mg which was adjusted during the treatment based on each patient's evaluation. T...

Objectives: Hepatitis C Virus (HCV) is a health problem among patients undergoing rehabilitation through methadone maintenance treatment in Iran, the most populous Persian Gulf country. The study aimed to examine gender differences among a group of methadone maintenance treatment patients with HCV problem. Methods: Overall 150 patients (n=75 men, n=75 women) were enrolled from nine methadone c...

AIMS To compare the efficacy of slow-release oral morphine (SROM) and methadone as maintenance medication for opioid dependence in patients previously treated with methadone. DESIGN Prospective, multiple-dose, open label, randomized, non-inferiority, cross-over study over two 11-week periods. Methadone treatment was switched to SROM with flexible dosing and vice versa according to period and ...

OBJECTIVES To describe and evaluate a pilot methadone maintenance program for heroin-dependent inmates of Las Malvinas men's prison in San Juan, Puerto Rico. METHODS Data from self-report of inmates' drug use before and during incarceration, attitudes about drug treatment in general and methadone maintenance in particular, and expectations about behaviors upon release from prison and from tes...

background: clopidogrel is a prodrug that converts in the liver to an active thiol metabolite, which irreversibly inhibits the platelet p2y12 adenosine diphosphate receptor. it seems that methadone as cyp2c19 inhibitor affects ticlopidine activity in vivo. this study aimed to test the ability of methadone in changing ticlopidine pharmacokinetics. methods: we conducted a case–control study in 10...

Background: Methadone maintenance has received little scientific attention regarding neurocognitive effects. This study is aimed to assess the neuropsychological performance of methadone maintenance patients (MMP) compared to those healthy controls. Methods: Thirty-five MMP and 35 healthy controls, matched for age, gender, education and employment status, examined on a battery of tests aimed at...

The relationship of methadone dose with post-mortem blood concentration was investigated using data collected from 1994 coronial cases in the Australian state of New South Wales. Data on 31 subjects were summarized using linear regression. The weight-adjusted methadone dose, gender, methadone maintenance treatment status and its interaction with adjusted-dose were all significant predictors of ...