BACKGROUND Opiate dependence is a major health and social issue in many countries. A mainstay of therapy has been methadone maintenance treatment, but other treatments, particularly buprenorphine, are increasingly being considered. AIM To conduct a systematic review to synthesise and critically appraise the evidence on the effectiveness of community maintenance programmes with methadone or bu...

BACKGROUND Methadone maintenance was the first widely used form of opioid replacement therapy developed to treat heroin dependence, and it remains the best-researched treatment for this problem. Despite the widespread use of methadone in maintenance treatment for opioid dependence in many countries, it is a controversial treatment whose effectiveness has been disputed. OBJECTIVES To evaluate ...

To the Editor: Quetiapine is a widely used antipsychotic and mood stabilizing compound. So far, false-positive methadone urine drug screens during quetiapine therapy have been described for 3 adults1 and 12 adolescents.2 Here, we report a case series of 10 inpatients, 4 men and 6 women from 22 to 48 years old, suffering from mood or psychotic disorders who tested positive for methadone. Since s...

background: the retention rates are important factors in methadone maintenance treatment. this study was performed with aims to determine the attitude and subjective norms in methadone treatment maintenance among kohgilouyeh and boyer ahmad’s province addict who referred addiction treatment centers. methods: this research was a cross-sectional study that done among men’s addicted who are receiv...

DESCRIPTION An independent panel developed cardiac safety recommendations for physicians prescribing methadone. METHODS Expert panel members reviewed and discussed the following sources regarding methadone: pertinent English-language literature identified from MEDLINE and EMBASE searches (1966 to June 2008), national substance abuse guidelines from the United States and other countries, infor...

tion was removed in 1976; physicians with appropriate Drug Enforcement Agency registration may now prescribe methadone for analgesia.3 The unique pharmaco kinetic and pharmacodynamic characteristics of methadone make it a valuable option for the management of chronic pain both as a first-line agent and as a replacement opioid.1,4 Even though methadone may be administered by several routes––oral...

Methadone and buprenorphine are widely used for treating people with opioid dependence, including pregnant women. Prenatal exposure to opioids has devastating effects on the development of human fetuses and may induce long-term physical and neurobehavioral changes during postnatal maturation. This study aimed at comparing the behavioral outcomes of young rats prenatally exposed to buprenorphine...

The safety, efficacy, and tolerability of nelfinavir (NFV)-containing antiretroviral therapy were evaluated in patients coinfected with HIV and hepatitis C undergoing methadone maintenance at an urban outpatient opioid treatment program serving a minority adult population. Eligibility covered methadone-maintained patients coinfected with HIV and hepatitis C who had received or were currently re...