In the present study we analyzed some circulating lymphocyte subsets in eleven patients affected by Graves' disease before and after three and six months of methimazole treatment. Peripheral blood mononuclear cells were studied by a panel of monoclonal antibodies with single and double fluorescence cytometric analysis. Our results demonstrated an increased percentage of CD5+B cells and HLADR+T ...

Preliminary Communications MEDICBJOURNAL 291 Phree radioactive compounds could be detected in chromato-grams of the urine after administration of 35S methimazole, of which two were probably 35S methimazole and VISO4. The third compound could be detected at the origin after the urinary sulphate had been removed by precipitation with barium chloride. After administration of propylthiouracil chror...

We report a case of drug-induced lupus (DIL) on a Chinese woman caused by methimazole (MMI). This report discusses DIL associated with MMI and briefly reviewed the literature concerning to anti-thyroid DIL.

The effect of isoniazid and rifampicin on metabolism dependent hepatotoxicity of methimazole (MMI) was studied in BALB/c mice. Hepatic damage was induced by single intraperitoneal dose of MMI (1000mg/kg). Pretreatment with isoniazid and rifampicin was carried out in separate groups for ten days and six days respectively prior to administration of methimazole. The extent of liver injury was dete...

Accepted January 4, 2012 The effect of supplementation with a fixed combination of antioxidants (beta-carotene, selenium, vitamins C and E) on serum lipids was monitored in patients with newly detected Graves’ disease. Measurements were made prior to the commencement of therapy and after 30 and 60 days. Patients were randomized into two groups. Test group comprised patients who received antioxi...

A 41-year-old man with a history of hyperthyroidism had been treated with methimazole and propranolol for the past 2 months. He developed multiorgan dysfunction with acute liver failure, severe lactic acidosis, disseminated intravascular coagulation, heart failure and acute pulmonary edema with rapid deterioration of renal function. The patient had no history of alcoholism, drug abuse, blood tr...

An immunocytochemical and morphometric study of pituitary GH-expressing cells was carried out in adult rats following chronic treatment with methimazole. The morphological results were correlated to the basal GH serum levels. In both sexes, hypothyroidism induced by methimazolee produced a significant decrease of GH serum levels in relation to untreated animals (p<0.05). Morphometrically, methi...