methylguanine

Exposure of III29 cells in culture to O'-methylguanine is known to result in a reduction in O'-alkylguanine-DNA alkyltransferase (AGT) activity and an enhancement of sensitivity to the cytotoxic effects of chloroethylating agents. Since cytotoxicity of these agents may be me diated by the formation of interstrand cross-links, alkaline elution analy sis was performed on HT29 cells treated with l...

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Pharmacologic disruption of base excision repair sensitizes mismatch repair-deficient and -proficient colon cancer cells to methylating agents.

Journal: :Clinical cancer research : an official journal of the American Association for Cancer Research 1999

L Liu P Taverna C M Whitacre S Chatterjee S L Gerson

Previously we showed that a mismatch repair (MMR)-deficient cell line, HCT116 (hMLH1 mut), unlike a MMR wild-type cell line, SW480, was more resistant to the therapeutic methylating agent, temozolomide (TMZ), because the MMR complex fails to recognize TMZ-induced O6-methylguanine DNA adduct mispairings with thymine that arise after replication. TMZ also produces N7-methylguanine and N3-methylad...

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O-methylguanine-DNA methyltransferase activity is associated with response to alkylating agent therapy and with MGMT promoter methylation in glioblastoma and anaplastic glioma

2014

Michael S. Bobola Mohammad Alnoor John Y.-S. Chen Douglas D. Kolstoe Daniel L. Silbergeld Robert C. Rostomily Marc C. Chamberlain John R. Silber

Abbreviations: AG, anaplastic glioma; BCNU, 1,3-bis( CCNU, 1-(2-chloroethyl)-3-cyclohexyl-1-nitrosourea; G ratio; O-meG, O-methylguanine; MGMT, O-methylgu MSP,methylation-specific PCR; PFS, progression-free surv temozolomide ⁎ Corresponding author at: Department of Neurol Washington, Box 356470, 1959 NE Pacific Street, Se Fax: +1 206 543 8315. E-mail address: [email protected] (J.R. Sil...

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