Periocular haemangiomas of infancy can cause severe and rapid ocular damage. Oral corticosteroids remain the front-line treatment to minimize the consequences of these haemangiomas. The aim of this report is to summarize our experience with pulse intravenous methylprednisolone as an alternative therapy for periocular haemangioma when visual prognosis is engaged. Fifteen infants, who presented p...

The plasma levels of soluble antiapoptotic Fas (sFas) and proapoptotic Fas-ligand (sFasl) proteins were studied in heart transplant recipients at one-month follow-up. The patients were treated with Neoral (n=18) or Tacrolimus (n=12) and concomitant immunosuppressive drugs. The sFas and sFasl levels were detected by ElISA. The values were related to treatment with Neoral or Tacrolimus in stable ...

It has been reported that plasma endotoxin, measured by Limulus amoebocyte lysate assays, markedly increased during extracorporeal circulation (ECC). Therefore, this study was undertaken to see if pretreatment with methylprednisolone 30 mg kg-1 modifies the endotoxaemia and associated increases in plasma cytokines in 17 patients undergoing cardiac surgery requiring ECC. We found that methylpred...

BACKGROUND Lower impacted third molar surgical extraction usually causes post-surgical sequelae like pain, trismus and swelling as a result of postoperative inflammatory response. OBJECTIVE The aim of this study was to evaluate and compare the efficacy of single dose 40-mg (1 cc) of methylprednisolone acetate, injected into the masseter muscle, preoperatively one hour before the surgery or po...

AIM To evaluate the neuroprotective effects of adalimumab in an experimental spinal cord injury model and compare them with those of the widely-used methylprednisolone. MATERIAL AND METHODS Forty male Wistar rats were divided into 5 as the sham, trauma, adalimumab, methylprednisolone, and adalimumab+methylprednisolone groups. Only laminectomy was performed in the sham group. Laminectomy and t...

BACKGROUND Andes virus (ANDV)-related hantavirus cardiopulmonary syndrome (HCPS) has a 35% case fatality rate in Chile and no specific treatment. In an immunomodulatory approach, we evaluated the efficacy of intravenous methylprednisolone for HCPS treatment, through a parallel-group, placebo-controlled clinical trial. METHODS Patients aged >2 years, with confirmed or suspected HCPS in cardiop...