miconazole is an imidazole antifungal agent, commonly applied topically to the skin or mucous membranes. the aim of this study was to examine the alternative method for gaining mechanism or the bimolecular changes caused by the possible teratogenic effects of miconazole on mice fetus brain tissue using ftir-microspectroscopy. the mice were injected with miconazole (60 mg/kg) on gestation day 9....

Lax, Antonio, Fernando Soler, and Francisco Fernandez-Belda. Inhibition of sarcoplasmic reticulum Ca2 ATPase by miconazole. Am J Physiol Cell Physiol 283: C85–C92, 2002. First published February 20, 2002; 10.1152/ ajpcell.00580.2001.—The inhibition of sarcoplasmic reticulum Ca2 -ATPase activity by miconazole was dependent on the concentration of ATP and membrane protein. Half-maximal inhibition...

BACKGROUND AND OBJECTIVE Miconazole is a broad-spectrum antifungal drug that has poor aqueous solubility (<1 µg/mL); as a result, a reduction in its therapeutic efficacy has been reported. The aim of this study was to formulate and evaluate miconazole-loaded solid lipid nanoparticles (MN-SLNs) for oral administration to find an innovative way to alleviate the disadvantages associated with comme...

Abstract: Introduction: Miconazole Nitrate is prescribed as an antifungal agent in conventional dosage forms. To mask the disadvantages of sticky creams and their tendency to rub off, intelligent regimen needs be designed. Objectives: The present study aimed design, develop, characterize (0.5% w/v) film-forming spray for treatment superficial fungal infections nails, such Tenia Onychomycosis. M...

A simple extractive spectrophotometric method has been developed for the estimation of miconazole nitratein both pure and pharmaceutical preparation. The method is based on the formation of ion-pair complex of thedrug with acidic dye bromothymol blue (BTB) in acidic condition, followed by its extraction in organic solvent(chloroform). The absorbance was measured against the corresponding blank....

OBJECTIVE To examine the extra cost of using higher-priced drugs as initial therapy for dermatophyte infections, because the many available effective drugs vary considerably in cost. DESIGN Cost analysis from the purchaser's perspective, comparing two prototypical regimens to treat tinea pedis: one in which all patients initially receive a lower-priced drug and those with unresponsive infecti...

The equilibrium problems, characterized by recurring end-points, involved in the reaction of iron (III) with iodide make the batch iodometric determination of iron (III) unsuitable. Since the flow injection determination does not require attainment of steady state either for mixing of reagents or for the chemical reaction, the iodometric determination has been accurately and precisely performed...

We present the first lattice results of the spectrum of exotic vector mesons extracted from the molecular and diquark-antidiquark operators, with quark fields (cqc̄q̄), and (csc̄q̄)/(cqc̄s̄) respectively, in lattice QCD with exact chiral symmetry. Our results suggest that X(3872) and Y (4260) are in the spectrum of QCD, with JPC = 1++ and 1−− respectively. Moreover, we obtain the spectrum of heavier ...

We analyze the observations of near-surface peroxy acetyl nitrate (PAN) and its precursors in Beijing, China in August of 2007. The levels of PAN are remarkably high (up to 14 ppbv), surpassing those measured over other urban regions in recent years. Analyses employing a 1-D version of a chemical transport model (Regional chEmical and trAnsport Model, REAM) indicate that aromatic non-methane hy...