OBJECTIVE To assess whether the methodological changes of this new algorithm improves the results of a previously presented strategy. METHODS We enhance the image and filter out the green channel of the digital color retinography. Multitolerance thresholding was applied to obtain candidate points and make a seed growing region by varying intensities. We took 15 characteristics from each regio...

Retinal microaneurysms are the earliest clinical sign of diabetic retinopathy disease. Detection of microaneurysms is crucial for the early diagnosis of diabetic retinopathy and prevention of blindness. In this paper, a novel and reliable method for automatic detection of microaneurysms in retinal images is proposed. In the first stage of the proposed method, several preliminary microaneurysm c...

BACKGROUND Very little documentation of spontaneous regression of an angiomatous retinal lesion in v. Hippel-Lindau disease (VHL) exists. It is commonly believed that a spontaneous change of hemangiomas into fibrotic lesions occurred. PATIENTS/METHODS Follow-up examinations of four patients with VHL in the Freiburg VHL study were carried out. RESULTS A 16-year-old girl revealed a vascular l...

PURPOSE To report a case of conjunctival microangiopathy secondary to diabetes presenting as a red eye 5 years after glaucoma implant surgery for neovascular glaucoma. MATERIALS AND METHODS A 52-year-old Tongan male with a past history of neovascular glaucoma secondary to proliferative diabetic retinopathy underwent slitlamp examination and color photography of the anterior and posterior segm...

This paper introduces, and reports on the performance of, a novel combination of algorithms for automated microaneurysm (MA) detection in retinal images. The presence of MAs in retinal images is a pathognomonic sign of Diabetic Retinopathy (DR) which is one of the leading causes of blindness amongst the working age population. An extensive survey of the literature is presented and current techn...

The blood-retinal barrier plays an important part in the processes of retinal pathophysiology. A new clinical method for the study of the blood-retinal barrier by vitreous fluorophotometry appears to satisfy the necessary requirements in that it is quantitative and shows good reproducibility and high sensitivity. The application of this method to a series of diabetic patients with apparently "...

BACKGROUND Diabetic retinopathy (DR) is one of the leading causes of blindness in the United States and world-wide. DR is a silent disease that may go unnoticed until it is too late for effective treatment. Therefore, early detection could improve the chances of therapeutic interventions that would alleviate its effects. METHODOLOGY Graded fundus photography and systemic data from 3443 ACCORD...

Bleeding into the joints is common in patients with hemophilia. After total knee or elbow replacement, profuse intraarticular bleeding unresponsive to high-dose clotting factor replacement sometimes occurs. In some patients who have severely damaged elbow or knee joints the same profuse bleeding pattern can be seen. To control bleeding in these patients, selective catheterization with a microca...

There is an unusual vascular network at the base of the brain in patients with moyamoya disease. We detected various histologic lesions in the perforating arteries of 22 patients. Vessels showing rupture ranged from 50 to 530 microns in diameter; they were dilated, some had fibrin deposits in the wall, fragmented elastic laminae and attenuated media. Non-ruptured perforating arteries (diameter ...

Diabetic Kidney Disease (DKD), the most recently adopted term for Chronic Kidney Disease (CKD) in patients with Diabetes Mellitus (DM): it has a prevalence of 20-40% in this group, and leads to an overall Hazard Ratio of 3.16 (95% CI 3.0,3.4) for all-cause mortality adjusted by age and sex, compared to the general population in some countries [1,2]. Early recognition of clinical changes include...