Coculturing multiple cell types together in 3-dimensional (3D) cultures better mimics the in vivo microphysiological environment, and has become widely adopted in recent years with the development of organ-on-chip systems. However, a bottleneck in set-up of these devices arises as a result of the delivery of the gel into the microfluidic chip being sensitive to pressure fluctuations, making gel...

For the first time, a novel and efficient ionic liquid-based ultrasound-assisted in-situ solvent formation microextraction (IL-UA-ISFME) combined with high-performance liquid chromatography-ultraviolet detection (HPLC-UV) has been successfully developed for the determination of duloxetine (DLX) in human plasma. Herein, an environmentally-friendly hydrophobic ionic liquid (1-butyl-3-methylimidaz...

The present research describes the use of directly suspended drop microextraction and air-assisted dispersive liquid-liquid microextraction method coupled with UV-Vis spectrophotometer for the analysis of doxepin in water and biological samples. Several important parameters which influence the extraction efficiencies of these two microextraction methods, such as the kind of extracting solven...

Using an automated rapid headspace solid phase microextraction (SPME) method for volatile extraction in cantaloupes, 86 compounds already reported for muskmelons were recovered and an additional 53 compounds not previously reported were identified or tentatively identified. The SPME method extracted a copious number of volatiles that can be analyzed to clearly differentiate between variety, gro...

1 Regulation 6 of the Genetically Modified Organisms (Contained Use) Regulations 2000, GMO(CU), requires that a suitable and sufficient assessment of the risks to human health and the environment be carried out before any activity involving genetic modification of micro-organisms is commenced. The assessment must take into account the matters in Part I of Schedule 3 and include the steps in Par...

abstractthe oldest method for the managing of the illness is the use of medicinal plants. the use of herbal products as the first choice in self-treatment of minor conditions continues to expand rapidly across iran. this makes the safety of herbal products an important public health issue.pesticides are used widely in agriculture to increase the production by controlling the harmful insects and...

dracocephalum kotschyi (lamiaceae), as one of the remarkable aromatic plants, widely grows and also is cultivated in various temperate regions of iran. there are diverse reports about the composition of the oil of this plant representing limonene derivatives as its major compounds. there is no report on cloning of mono- or sesquiterpene synthases from this plant. in the present study, the aroma...

Human exposures to volatile organic compounds (VOCs) are associated with a wide range of health problems. Due to these adverse effects of VOCs on the human health, determination of trace levels of VOCs is very important for accurate assessment of indoor and outdoor exposure. Solid phase microextraction (SPME), needle trap device (NTD) and hollow fiber- liquid phase microextraction (HF-LPME) are...

A novel sorbent in solid phase microextraction (SPME) method based on poly(3-alkylthiophenes) was used in the isolation of linezolid from human plasma samples following liquid chromatography determination. The effect of extraction time on the sorption capacity of the SPME process was studied and pointed at 10 min both for adsorption and desorption. Poly(3-methylthiophene) and poly(3-nonylthioph...

Measurements of rain were obtained with a vertically pointing micro radar (MRR) with 1 min time resolution and 50(100) m height resolution at the German Baltic coast on the Zingst peninsula (54.43°N, 12.67°E). The comparison with a conventional rain gauge (30 min integration time) for a fi ve months summer period show a correlation coeffi cient of r = 0.87 for the rainrate and agreement within ...