Strong acoustic streaming can be generated inside a microchannel near sharp-edge structures. In this study, three Sharp-Edge Acoustic Streaming (SEAS) micromixers with multiple sharp edge patterns actuated by piezoelectric transducers are investigated. Direct Numerical Simulation (DNS) is used to numerically solve the multi-physics phenomenon involving acoustics, fluid dynamics and mass transfe...

Crystallization is a key unit operation in the pharmaceutical industry. Control of crystallization processes can be challenging when undesirable phenomena such as particle attrition and breakage occur. This thesis describes the controlled crystallization of pharmaceuticals and amino acids for more efficient manufacturing processes and better efficacy of products. Crystallization equipment is de...

Lipid nanoparticles (LNPs) or liposomes are the most widely used drug carriers for nanomedicines. The size of LNPs is one of the essential factors affecting drug delivery efficiency and therapeutic efficiency. Here, we demonstrated the effect of lipid concentration and mixing performance on the LNP size using microfluidic devices with the aim of understanding the LNP formation mechanism and con...

Micromixers are crucial parts of microfluidic systems when it comes to efficiency and precision, as mixing is the central process in most relevant applications, including medical diagnosis, chemical production, drug discovery. In view importance improving quality, for first time, present work investigates simultaneous effects chamber geometry (circular, hexagonal, octagonal), electric field fre...

3D velocity field measurements in an arrow-type micromixer are performed using nuclear magnetic resonance (NMR) imaging methods. A specific device has been set up including a home-made radiofrequency milli-coil matching the geometry of manufactured micromixer, allowing improvement signal-to-noise ratio by factor 7 comparing to standard commercial hardware. The NMR images obtained compared compu...

Microfluidic devices where the microchannel walls were decorated with micro and nanostructures were fabricated using 3D nanomolding. Using 3D molded microfluidic devices with microchannel walls decorated with microscale gratings, the fluid mixing behavior was investigated through experiments and numerical simulation. The use of microscale gratings in the micromixer was predicated by the fact th...

Micromixers with floor-grooved microfluidic channels have been successfully demonstrated in experiment. In this work, we numerically simulated the mixing within the devices and used the obtained concentration versus channel length profiles to quantitatively characterize the process. It was found that the concentration at any given cross-section location of the microfluidic channel periodically ...