Endoxifen has recently been identified as the predominant active metabolite of tamoxifen and is currently being developed as a novel hormonal therapy for the treatment of endocrine sensitive breast cancer. Based on past studies in breast cancer cells and model systems, endoxifen classically functions as an anti-estrogenic compound. Since estrogen and estrogen receptors play critical roles in me...

Dissociated agonists of the glucocorticoid receptor (DAGRs) show similar antiinflammatory effects but improved tolerability compared with standard glucocorticoid receptor (GR) agonists. The prodrug fosdagrocorat (PF-04171327), with active DAGR metabolite PF-00251802 (Metabolite-1), is postulated to show superior efficacy over placebo and prednisone in patients with moderate to severe rheumatoid...

The purpose of this study was to examine associations among bone mineral density, osteopenia/osteoporosis, body mass index (BMI), and body composition in patients with heart failure (HF). A total of 119 patients (age = 61 ± 12 years, 65% male) underwent dual-energy X-ray absorptiometry scans to determine bone mineral density and body composition. In multivariable linear regressions, BMI, relati...

In the present study effect of feeding area specific mineral mixture on the serum mineral status of cattle in different agro climatic zones (plateau, plain and hills) of Chhattisgarh state was studied. The soil and fodder mineral status of different zones were analyzed. Macro minerals were below desired level in soil of hill region followed by plateau and plain whereas Mg level in soils of diff...

abstract background: increase in nitric oxide (no) concentration accompanied by alteration in peritoneal immune defense reactions is involved in the pathogenesis of endometriosis. asymmetric dimethylarginine is an endogenous competitive inhibitor of no synthase. this study was designed to compare no metabolite (nitrite), asymmetric dimethylarginine, and estradiol concentrations in serum and per...

background: to investigate the relationship between renal stone formation and osteoporosis. methods: eight hundred thirty healthy subjects aged between 20 and 76 years were randomly selected from 50 clusters to take part in the study. of these, 68 (8.2%) had a previous history of renal stone disease. all participants underwent clinical exami nation and bone mineral densitometry of the lumbar sp...

background : the role of minerals on parasite persistency and the interaction between minerals and animal responses to the parasite infestation is not clear. for these reasons, the present re­search was aimed to compare copper, zinc and iron status in sheep with parasitic myocarditis and healthy ones in 2009. methods : blood and heart tissue samples were collected from 145 slaughtered sheep and...