Mint adaptor proteins bind to the membrane-bound amyloid precursor protein (APP) and affect the production of pathogenic amyloid-β (Aβ) peptides related to Alzheimer's disease (AD). Previous studies have shown that loss of each of the three Mint proteins delays the age-dependent production of amyloid plaques in transgenic mouse models of AD. However, the cellular and molecular mechanisms underl...

Several hundred PDZ (postsynaptic density-95, Drosophila disks-large, ZO-1) domain-containing proteins have been identified in the human genome. PDZ domains play a critical role in organization and function of cellular signaling pathways. Thus, small molecule inhibitors of PDZ domain association with their targets have wide potential applications as research and therapeutic agents. PDZ domains ...

BACKGROUND Essential oils, as secondary plant compounds, present a safer alternative to conventional insecticides in insect control programs. So five essential oils including eucalyptus, mint, yarrow, oregano and rosemary oils were evaluated against the brown-banded cockroach Supella longipalpa. METHODS Evaluation was done against the 3rd and 4th instar nymphs using three bioassay methods; co...

This study is intended to prevent ochratoxin A (OTA) production by Aspergillus carbonarius S402 using essential oils (EOs) and total phenolic compounds extracted from plants and herbs. The EOs used in this study are the following: bay leaves, cumin, fenugreek, melissa, mint, and sage. As for the phenolic compounds, they were extracted from bay leaves, cumin, fenugreek, melissa, mint, sage, anis...

Ebben a tanulmányban megvizsgáljuk azt nyelvezetet, amelyet Ptolemaiosz használt katalógusában csillagok leírására. A katalógust eddig behatóan vizsgálták benne található adatok tekintetében, ám szöveges leírásokra nem sok koncentrált figyelem irányult. Mi az ún. anatómiai leírásokat vesszük szemügyre (több mint 700 darab): ezek olyan szövegrészletek, melyek azáltal azonosítják tárgyukat, azaz ...