We unraveled the expression profiles of coding-noncoding RNAs in intervertebral disc degeneration (IDD). However, it remains elusive regarding miR-155 peripheral blood mononuclear cells (PBMCs) and local extracellular space IDD. The study aimed for investigating PBMCs, miRNAs (ex-miRNAs) human nucleus pulposus (NP) tissues, morphological changes cell death IDD process. Here, we harvested NP sam...

Carcinoma of the stomach is one of the major prevalent and principal causes of cancer-related deaths worldwide. Current advancement in technology has improved the understanding of the pathogenesis and pathology of gastric cancers (GC). But, high mortality rates, unfavorable prognosis and lack of clinical predictive biomarkers provide an impetus to investigate novel early diagnostic/prognostic m...

Background: Toll-like receptors (TLRs) detect diverse pathogen-associated molecular patterns and play a critical role in the innate immune response. Hosts should activate TLR-signaling pathways to eliminate invading pathogens. However, excessive activation of these pathways may interrupt immune homeostasis, leading to several diseases. Therefore precise regulation of TLR-signaling pathways is e...

MicroRNAs (miRNAs) are known as single-stranded RNA molecule functional in all steps of plant life including growth, development, and stress responses. Plant genomes harbor hundreds miRNAs, which have diverse functions regulating numerous biological processes. After being first discovered plants by the year 2002, thousands miRNAs been identified so far. With help recent advances high-throughput...

MicroRNAs (miRNAs) are small single-stranded, non-coding RNA molecules involved in the pathogenesis and progression of cancer, including osteosarcoma. We aimed to clarify pathways involving miRNAs using new bioinformatics tools. applied WikiPathways PathVisio, two open-source platforms, analyze osteosarcoma miRTar ONCO.IO as integration found 1298 records papers associated with word “miRNA”. In...

BACKGROUND MicroRNAs (miRNAs) play crucial roles in various physiological processes through post-transcriptional regulation of gene expressions and are involved in development, metabolism, and many other important molecular mechanisms and cellular processes. The Bombyx mori genome sequence provides opportunities for a thorough survey for miRNAs as well as comparative analyses with other sequenc...

Abstract MicroRNAs (miRNAs) are essential nonprotein-coding genes. In a range of organisms, miRNAs has been reported to play an role in regulating gene expressions at post-transcriptional level. They participate most the stress responsive processes plants. Drought is ultimate abiotic that affects crop production. Therefore understanding drought responses improve production agricultural crops. T...

MicroRNAs (miRNAs), a class of non-coding small endogenous RNAs of approximately 22 nucleotides, regulate gene expression at the post-transcriptional levels by targeting mRNAs for degradation or by inhibiting protein translation. Thousands of miRNAs have been identified in many species. However, there is no information available concerning miRNAs in ma bamboo (Dendrocalamus latiflorus), one of ...

Circulating RNAs in human body fluids are promising candidates for diagnostic purposes. However, the biological significance of circulating RNAs remains elusive. Recently, small non-coding RNAs, microRNAs (miRNAs), were isolated from multiple human body fluids, and these "circulating miRNAs" have been implicated as novel disease biomarkers. Concurrently, miRNAs were also identified in the extra...

MicroRNAs (miRNAs) are short, non-coding single-strand RNA molecules that play important roles in plant growth, development and stress responses. Flowering time affects the seed yield and quality of soybean. However, the miRNAs involved in the regulation of flowering time in soybean have not been reported until recently. Here, high-throughput sequencing and qRT-PCR were used to identify miRNAs ...